Results 71 to 80 of about 12,333 (188)
mBio, 2018 Pseudomonas aeruginosa is internalized into multiple types of epithelial cell in vitro and in vivo and yet is often regarded as an exclusively extracellular pathogen.
Abby R. Kroken +4 more
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Characterization of the two conformations adopted by the T3SS inner‐membrane protein PrgK [PDF]
Protein Science, 2018 AbstractThe pathogenic bacterium Salmonella enterica serovar Typhimurium utilizes two type III secretion systems (T3SS) to inject effector proteins into target cells upon infection. The T3SS secretion apparatus (the injectisome) is a large macromolecular assembly composed of over twenty proteins, many in highly oligomeric states. A sub‐structure of the
Julien R. C. Bergeron +7 more
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Microorganisms, 2018 Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic Escherichia coli (EPEC) are attaching and effacing (A/E) pathogens, which translocate effector proteins to intestinal enterocytes through a type III secretion system (T3SS).
Mariano Larzábal +3 more
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Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
PLOS ONE, 2020 Type three secretion systems (T3SS) are complex nano-machines that evolved to inject bacterial effector proteins directly into the cytoplasm of eukaryotic cells. Many high-priority human pathogens rely on one or more T3SSs to cause disease and evade host immune responses, underscoring the need to better understand the mechanisms through which T3SSs ...
Jamie L. Burgess +3 more
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Frontiers in Microbiology, 2019 Many gram-negative pathogens utilize a protein complex, termed the type III secretion system (T3SS), to inject virulence factors from their cytoplasm directly into the host cell.
Irit Tseytin +6 more
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Live‐Cell Fluorescent Visualization of T3SS Needle and Its Dynamics
The FASEB Journal, 2019 The Type III Secretion System (T3SS) is a complex transmembrane apparatus used by many Gram‐negative pathogens for protein translocation and host invasion. An essential T3SS component is the needle, a hollow substructure extending from the bacterial membrane, spanning the space from the bacterium to the host cytosol.
Dorothy Cheng +2 more
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Molecular Plant-Microbe Interactions, 2011 Xanthomonas albilineans is the causal agent of sugarcane leaf scald. Interestingly, this bacterium, which is not known to be insect or animal associated, possesses a type III secretion system (T3SS) belonging to the injectisome family Salmonella ...
Mélanie Marguerettaz +8 more
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Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
mBio, 2017 The type three secretion system (T3SS) is critical for the virulence of diverse bacterial pathogens. Pathogens use the T3SS to deliver effector proteins into host cells and manipulate host signaling pathways.
Melissa M. Kendall
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VopX, a novel Vibrio cholerae T3SS effector, modulates host actin dynamics
mBioABSTRACT Pathogenic Vibrio cholerae strains cause cholera using different mechanisms. O1 and O139 serogroup strains use the toxin-co-regulated pilus (TCP) and cholera toxin (CT) for intestinal colonization and to promote secretory diarrhea, while non-O1/non-O139 serogroup ...
Megan Ulbrich +5 more
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Lon Protease Is Involved in RhpRS-Mediated Regulation of Type III Secretion in Pseudomonas syringae
Molecular Plant-Microbe Interactions, 2016 Pseudomonas syringae depends on the type III secretion system (T3SS) to directly translocate effectors into host cells. Previously, we reported a nonpathogenic rhpS mutant, suggesting that the two-component transduction system rhpRS is an important ...
Tianhong Zhou +9 more
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