Results 91 to 100 of about 335,535 (207)
Advanced Science, EarlyView.Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng +11 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu +10 more
wiley +1 more source
Advanced Science, EarlyView.Achieving high‐efficiency deep‐blue phosphorescent OLEDs is limited by intermolecular kinetic bottlenecks. We overcome this using a single‐molecule fused emitter architecture, Pt‐SP‐tCz, combining a p‐type host and Pt(II) dopant. This design enables zero‐radius intramolecular energy transfer (ZRIET) and a novel ZETPLEX mechanism.
You Na Song +9 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source
Advanced Science, EarlyView.This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.
Guoliang Zheng +20 more
wiley +1 more source
Ergodicity, lack thereof, and the performance of reservoir computing with memristive networks
Nano ExpressNetworks composed of nanoscale memristive components, such as nanowire and nanoparticle networks, have recently received considerable attention because of their potential use as neuromorphic devices.
Valentina Baccetti +3 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng +8 more
wiley +1 more source
Time Resolved DNA Barcodes for Information Encoding and Dynamic Encryption
Advanced Science, EarlyView.This study establishes a molecular information platform based on DNA Temporal Barcodes. Information is encoded through combinations of DNA tags with distinct retention times, while dynamic encryption is achieved through a key‐triggered DNA ligation.
Likang Chu +7 more
wiley +1 more source
A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics
Advanced Science, EarlyView.A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma +22 more
wiley +1 more source
Advanced Science, EarlyView.The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li +4 more
wiley +1 more source