Results 81 to 90 of about 995,836 (254)

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Uptake of thyroxine in cultured anterior pituitary cells of euthyroid rats [PDF]

, 1994
The uptake of [125I]T4 was investigated in cultured anterior pituitary cells isolated from adult fed Wistar rats and cultured for 3 days in medium containing 10% fetal calf serum. Experiments were performed with [125I]T4 (10(
Docter, R. (Roel), Everts, M.E. (Maria), Hennemann, G. (George), Jong, M. (Marcel) de, Koetsveld, P.M. (Peter) van, Krenning, E.P. (Eric), Moerings, E.P.C.M. (Ellis), Visser, T.J. (Theo)   +7 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Type IIB orbifolds with D5-branes and their string duals [PDF]

, 2000
We consider Z2, freely acting orbifolds of the type IIB string with 16 parallel D5-branes. When the string is compactified on T2 X T4 and the D5-branes are wrapped on T2, these systems possess N=2 supersymmetry, originating from the spontaneous, partial ...
Gregori, Andrea
core   +2 more sources

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

To study effects of metformin on thyroid functions in type-2 diabetes mellitus in patients attending OPD at Government Medical College, Bidar

Journal of Family Medicine and Primary Care
Introduction: Metformin is one of the most used diabetes treating agents and has proved to be very effective, with a wide spectrum of efficacy, safety as well as being as agent that works at different spots in diabetes pathogenesis paradigm.
Prashant Patil, Sachin Gudage, Mahesh B. Tondare, Sangamesh B. Tondare, Praveen Ganganahalli   +4 more
doaj   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice

European Thyroid Journal
Objective: Mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) cause Allan–Herndon–Dudley syndrome (AHDS), a severe form of psychomotor retardation with muscle hypoplasia and spastic paraplegia as key symptoms.
Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Heike Heuer   +3 more
doaj   +1 more source

Lectures on Non-BPS Dirichlet branes [PDF]

, 2000
A comprehensive introduction to the boundary state approach to Dirichlet branes is given. Various examples of BPS and non-BPS Dirichlet branes are discussed.
(Alekseev A, (Blum J D, (Fuchs J, Aldazabal G, Aldazabal G, Aldazabal G, Aldazabal G, Alekseev A, Alekseev A, Angelantonj C, Angelantonj C, Antoniadis I, Aspinwall P S, Banks T, Berenstein D, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Bergman O, Berkovits N, Bianchi M, Billo M, Blum J D, Blumenhagen R, Brunner I, Dai J, Dasgupta T, Di Vecchia P, Di Vecchia P, Diaconescu D, Diaconescu D, Douglas M, Douglas M, Douglas M, Erdéli A, Eyras E, Felder G, Frau M, Gaberdiel M R, Gaberdiel M R, Gaberdiel M R, Gaberdiel M R, Gaberdiel M R, Gaberdiel M R, Green M B, Green M B, Gukov S, Gutperle M, Harvey J, Harvey J, Harvey J A, Horava P, Horava P, Ishibashi N, Kachru S, Kachru S, Kachru S, Kachru S, Kachru S, Kachru S, Klebanov I R, Klebanov I R, Klebanov I R, Klebanov I R, Lerda A, Li M, Lowe D A, Majumder J, Majumder J, Maldacena J M, Maldacena J M, Maldacena J M, Matthias R Gaberdiel, Mukhi S, Mukhi S, Mukhi S, Onogi T, Onogi T, Polchinski J, Polchinski J, Polchinski J, Pradisi G, Pradisi G, Recknagel A, Sagnotti A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Sen A, Strathdee J, Witten E, Witten E, Witten E, Witten E   +114 more
core   +4 more sources

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source