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T6SS-effector hunters uncover PIX: a novel delivery/marker domain
Trends in MicrobiologyGram-negative bacteria use the T6SS to eject effectors into prey cells, aided by delivery domains. Recently uncovered by Carobbi et al., a new delivery domain, PIX, allowed the identification of hundreds of new effectors. They are order- and function-specific and exclusively orphan effectors, raising novel questions in the field.
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Proceedings of the National Academy of Sciences of the United States of America, 2021
Xihui Shen, Zhengfan Jiang
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Xihui Shen, Zhengfan Jiang
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Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa
Proceedings of the National Academy of Sciences of the United States of America, 2021Anne-Sophie Stolle +2 more
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A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan
Cell Reports, 2020Ankur Patel +2 more
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Structure of the T6SS lipoprotein TssJ1 fromPseudomonas aeruginosa
Acta Crystallographica Section F: Structural Biology Communications, 2013Alisdair Boraston +2 more
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Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut
Proceedings of the National Academy of Sciences of the United States of America, 2016Kyler A Lugo +2 more
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Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae
Proceedings of the National Academy of Sciences of the United States of America, 2013Deborah Yoder-Himes +2 more
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Multidrug-resistant plasmids repress chromosomally encoded T6SS to enable their dissemination
Proceedings of the National Academy of Sciences of the United States of America, 2019Ki Hwan Moon +2 more
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