Results 141 to 150 of about 8,261,953 (362)

A COMPARATIVE STUDY OF RED CELL VOLUMES IN HUMAN SUBJECTS WITH RADIOACTIVE PHOSPHORUS TAGGED RED CELLS AND T-1824 DYE 12 [PDF]

open access: bronze, 1950
Herman M. Nachman   +5 more
openalex   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Not All Immune Checkpoints Are Created Equal

open access: yesFrontiers in Immunology, 2018
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares   +3 more
doaj   +1 more source

The effects of MAPK activity on cell-cell adhesion during wound healing [PDF]

open access: yesarXiv, 2015
The mechanisms underlying collective migration, or the coordinated movement of a population of cells, are not well understood despite its ubiquitous nature. As a means to investigate collective migration, we consider a wound healing scenario in which a population of cells fills in the empty space left from a scratch wound.
arxiv  

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

COMPARATIVE-EVALUATION-OF-TWO-VIABILITY ASSAYS ON BIODEGRADABLE POLYMER FOAMS FOR POTENTIAL BONE REGENERATION

open access: yesRomanian Journal of Medical and Dental Education, 2014
The purpose of the present study was to evaluate comparatively the cytotoxicity of two foams prepared by phosphorylated cellulose and phosphorylated PVA using two common assays, MTT classic assay and Cell-titer blue assay.
Ana Maria Holicov   +2 more
doaj  

A mathematical study of CD8+ T cell responses calibrated with human data [PDF]

open access: yesarXiv, 2018
Complete understanding of the mechanisms regulating the proliferation and differentiation that takes place during human immune CD8+ T cell responses is still lacking. Human clinical data is usually limited to blood cell counts, yet the initiation of these responses occurs in the draining lymph nodes; antigen-specific effector and memory CD8+ T cells ...
arxiv  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

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