Results 201 to 210 of about 8,676,743 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Indolent peripheral T-cell lymphoma resembling Kimura's disease: a new variant of T-cell Lymphoma? [PDF]

Leuk Res Rep
Sun H, Feng J, Zhang Y, Zhang J, Lu S, Liu Y.   +5 more
europepmc   +1 more source

A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells [PDF]

, 2017
Liwei Wang, Jinliang Wang, Jing Chen, Jiajie Chen, Jia‐Wei Shen, Xiaoxiao Feng, Christian P. Kubicek, Fu‐Cheng Lin, Chu‐Long Zhang, Fengyang Chen   +9 more
openalex   +1 more source

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy

, 2021
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Peripheral T cell lymphoma following CD19-targeted chimeric antigen receptor T cell therapy. [PDF]

Int J Hematol
Tatetsu H, Kato K, Wada A, Hirano T, Ueno S, Miyasato Y, Yamada A, Shichijo T, Higuchi Y, Ueda Y, Nosaka K, Mikami Y, Karube K, Matsuoka M, Yasunaga JI.   +14 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Pleiotropic Roles of Cytokines in Chimeric Antigen Receptor T-cell Therapy. [PDF]

Cancer Immunol Res
Stewart CM, Siegler EL, Kenderian SS.
europepmc   +1 more source

Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression [PDF]

, 2013
Dimitrios N. Vatakis, Arumugam Balamurugan, Sohn G. Kim, Gregory Bristol, Otto O. Yang, Jerome A. Zack   +5 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source