Results 201 to 210 of about 4,664,465 (319)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Early Phase Dose-Finding Designs for CAR-T Cell Therapies. [PDF]

Pharm Stat
Chen W, Mozgunov P, Mullaert J, Paoletti X.   +3 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

T-Cell Immunity and Lung Cancer. [PDF]

Respirology
Yamada K, Togashi Y.
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma. [PDF]

BMC Med
Chan JY, Lee ECY, Chai KXY, Lim BY, Li Z, Lee JY, Kannan B, Tay HY, Ko TK, Kok JS, Lim KS, Taib NABM, Huang D, Lim JQ, Hazama M, Fukushima K, Teh BT, Lim ST, Ong CK.   +18 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Primary Cutaneous CD4⁺ Small/Medium T-cell Lymphoproliferative Disorder With T-cell Receptor (TCR) Clonality: The Importance of Clinical Context in Management. [PDF]

Cureus
Naidnur S, Martes-Villalobos C, Neave SA, DeSantis E, Lin R.   +4 more
europepmc   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Targeting TMED4 enhances CD8⁺ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis. [PDF]

Sci Adv
Wang H, Shi L, Jiang K, Wu S, Jiang Z, Tao Y, Li J, Li X, Liu J, Ni J, Wu EJ, Wu SJ, Chen G, Qin M, Xu L, Lai CH, Aicher A, Ye Y, Heeschen C, Cao YJ, Wu X.   +20 more
europepmc   +1 more source