Results 301 to 310 of about 8,713,756 (356)
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T-Cell Receptor–Transduced T Cells
The Cancer Journal, 2015The large number of T-cell epitopes that have been found to be processed and presented on human tumors, now numbering in the hundreds, provides a rich source of targets for therapeutic interventions aimed at inducing durable tumor regression. Vaccination strategies aimed at inducing responses to these antigens have been largely ineffective, and it has ...
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The American Journal of Medicine, 1988
Over the past few decades, a solid body of evidence has been built up linking certain autoimmune diseases to the presence of specific major histocompatibility complex haplotypes. Major histocompatibility complex products are used by the immune system to distinguish non-self from self and are important in the recognition of foreign antigen by T cells. T
N, Caccia, T W, Mak
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Over the past few decades, a solid body of evidence has been built up linking certain autoimmune diseases to the presence of specific major histocompatibility complex haplotypes. Major histocompatibility complex products are used by the immune system to distinguish non-self from self and are important in the recognition of foreign antigen by T cells. T
N, Caccia, T W, Mak
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New England Journal of Medicine, 2011
The pursuit of tumor-reactive T cells as a cancer therapy has continued unabated since the discovery of the graft-versus-leukemia effect in patients undergoing allogeneic hematopoietic stem-cell transplantation.1 Some successes have been noted: the adoptive transfer of Epstein–Barr virus (EBV)–specific T cells can prevent and treat post-transplantation
Walter J, Urba, Dan L, Longo
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The pursuit of tumor-reactive T cells as a cancer therapy has continued unabated since the discovery of the graft-versus-leukemia effect in patients undergoing allogeneic hematopoietic stem-cell transplantation.1 Some successes have been noted: the adoptive transfer of Epstein–Barr virus (EBV)–specific T cells can prevent and treat post-transplantation
Walter J, Urba, Dan L, Longo
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Annual Review of Immunology, 1998
▪ Abstract Immunological memory can be defined as the faster and stronger response of an animal that follows reexposure to the same antigen. By this definition, it is an operational property of the whole animal or the immune system. Memory cells express a different pattern of cell surface markers, and they respond in several ways that are functionally
R W, Dutton, L M, Bradley, S L, Swain
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▪ Abstract Immunological memory can be defined as the faster and stronger response of an animal that follows reexposure to the same antigen. By this definition, it is an operational property of the whole animal or the immune system. Memory cells express a different pattern of cell surface markers, and they respond in several ways that are functionally
R W, Dutton, L M, Bradley, S L, Swain
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Neurosurgery Clinics of North America, 2021
Chimeric antigen receptor T (CAR-T) cells, an immunotherapy that demonstrates marked success in treatment of hematologic malignancies, are an emergent therapeutic for patients with glioblastoma (GBM). GBM CAR-T trials have focused on targeting well-characterized antigens in the pathogenesis of GBM.
Thilan, Tudor +2 more
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Chimeric antigen receptor T (CAR-T) cells, an immunotherapy that demonstrates marked success in treatment of hematologic malignancies, are an emergent therapeutic for patients with glioblastoma (GBM). GBM CAR-T trials have focused on targeting well-characterized antigens in the pathogenesis of GBM.
Thilan, Tudor +2 more
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The Journal of Dermatology, 1980
AbstractCutaneous T cell lymphoma (CTCL) is a generic classification of clonally‐derived malignancies of phenotypic helper/inducer T cells with a propensity to infiltrate the skin, migrate into the epidermis, localize in T cell zones of lymphoid structures and spare the bone marrow.
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AbstractCutaneous T cell lymphoma (CTCL) is a generic classification of clonally‐derived malignancies of phenotypic helper/inducer T cells with a propensity to infiltrate the skin, migrate into the epidermis, localize in T cell zones of lymphoid structures and spare the bone marrow.
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Nature Immunology, 2011
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents optimal control of infection and tumors.
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T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents optimal control of infection and tumors.
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Immunology & Cell Biology, 2008
The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4+ and CD8+ cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various γc cytokines, plays a decisive role in ...
Jonathan, Sprent +3 more
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The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4+ and CD8+ cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various γc cytokines, plays a decisive role in ...
Jonathan, Sprent +3 more
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International Journal of Immunopharmacology, 1994
T-cell adjuvancy involves the use of agents to stimulate preferentially delayed type hypersensitivity (DTH). Traditional adjuvants like Alum, Freunds, muramyl peptides, and endotoxins are not selective. Natural infection (e.g. vaccinia) may yield selective DTH. Low dose cyclophosphamide (CY) with mycobacteria was the first experimental T-cell adjuvant.
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T-cell adjuvancy involves the use of agents to stimulate preferentially delayed type hypersensitivity (DTH). Traditional adjuvants like Alum, Freunds, muramyl peptides, and endotoxins are not selective. Natural infection (e.g. vaccinia) may yield selective DTH. Low dose cyclophosphamide (CY) with mycobacteria was the first experimental T-cell adjuvant.
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Current Opinion in Immunology, 1992
Despite the acceptance of principles such as clonal deletion in the thymus and peripheral clonal anergy, several new issues have arisen in the study of T-cell tolerance. For example, in the case of thymic tolerance, it is now clear that several distinct components of the thymus, including various subsets of thymic epithelial cells, can all make ...
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Despite the acceptance of principles such as clonal deletion in the thymus and peripheral clonal anergy, several new issues have arisen in the study of T-cell tolerance. For example, in the case of thymic tolerance, it is now clear that several distinct components of the thymus, including various subsets of thymic epithelial cells, can all make ...
openaire +2 more sources