Results 291 to 300 of about 4,664,465 (319)

T-Cell Receptor–Transduced T Cells

The Cancer Journal, 2015
The large number of T-cell epitopes that have been found to be processed and presented on human tumors, now numbering in the hundreds, provides a rich source of targets for therapeutic interventions aimed at inducing durable tumor regression. Vaccination strategies aimed at inducing responses to these antigens have been largely ineffective, and it has ...
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T-cell-T-cell collaboration in allograft responses

Current Opinion in Immunology, 1993
T-cell-T-cell collaboration in allogeneic responses traditionally has been viewed as the requirement for CD4+ T helper cells in the activation of CD8+ cytotoxic T cells. In this regard, the role of the CD4+ T cell is primarily to provide growth factors, such as interleukin-2, on which the CD8+ T cell is dependent.
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Functional T Cell Immunodeficiencies (with T Cells Present)

Annual Review of Immunology, 2013
Severe combined immunodeficiency (SCID) comprises a group of disorders that are fatal owing to genetic defects that abrogate T cell development. Numerous related defects have recently been identified that allow T cell development but that compromise T cell function by affecting proximal or distal steps in intracellular signaling.
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ZEB2 in T-cells and T-ALL

Advances in Biological Regulation, 2019
The identification of the rare but recurrent t(2; 14)(q22; q32) translocation involving the ZEB2 locus in T-cell acute lymphoblastic leukemia, suggested that ZEB2 is an oncogenic driver of this high-risk subtype of leukemia. ZEB2, a zinc finger E-box homeobox binding transcription factor, is a master regulator of cellular plasticity and its expression ...
Stien, De Coninck, Geert, Berx, Tom, Taghon, Pieter, Van Vlierberghe, Steven, Goossens   +4 more
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Impaired autoreactive T cell-induced T cell-T cell interaction in aged mice

Cellular Immunology, 1988
Self-Ia-reactive (autoreactive) L3T4+ T cell clones have been shown earlier to stimulate the proliferation of syngeneic naive L3T4+ T cells and initiate a T cell-T cell (T-T) interaction leading to the generation of immunoregulatory circuits. Since aging has been shown to be associated with a decline of the immune responsiveness, age-related ...
V, Udhayakumar, B, Subbarao, A, Seth, M, Nagarkatti, P S, Nagarkatti   +4 more
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The role of T-cell phenotype and T-cell receptor rearrangement in the diagnosis of T-cell malignancies

Leukemia & Lymphoma, 2015
We read with interest the article by Flammiger et al. [1] on the study of a series of patients with aberrant T-cell phenotype of unclear significance by flow cytometry (FC).
Marc, Sorigué, Jordi, Juncà, Silvia, Marcé, Marta, Cabezón, Olga, García, Lurdes, Zamora   +5 more
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Homotypic T-cell/T-cell interaction induces T-cell activation, proliferation, and differentiation

Human Immunology, 2009
Activated CD4 T cells might induce T-cell activation from CD4 resting T cells in the absence of antigen presenting cells through interaction of activation-induced surface molecules (e.g., CD80, CD86, CD70, major histocompatibility complex class II) and their ligands constitutively expressed on resting T cells.
Andreas, Ramming, Katja, Thümmler, Hendrik, Schulze-Koops, Alla, Skapenko   +3 more
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Thymus, T-Cell Differentiation and the T-Cell System

1982
Although it is not possible to say that passage through the thymus is the exclusive pathway that all T-lineage cells must follow, there is ample evidence that the thymus has a profound influence on the development of a fully competent T-cell system (reviewed in Cantor and Weissman, 1976; Stutman, 1978).
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T CELLS, T CELL SUBSETS AND IMMUNOREGULATION

Australian and New Zealand Journal of Medicine, 1984
P A, Gatenby, R E, Callard, A, Basten
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T cell homeostasis: Keeping useful T cells alive and live T cells useful

Seminars in Immunology, 2005
It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or ...
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