Results 271 to 280 of about 4,652,143 (319)
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2020
In 1891, Dr. William B. Coley, an American surgeon, made a compelling observation that immune system can be triggered to shrink tumors. The quest to exploit the power of immunotherapy however was forestalled by an era of chemotherapy that ensued.
Ranjit, Nair, Jason, Westin
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In 1891, Dr. William B. Coley, an American surgeon, made a compelling observation that immune system can be triggered to shrink tumors. The quest to exploit the power of immunotherapy however was forestalled by an era of chemotherapy that ensued.
Ranjit, Nair, Jason, Westin
openaire +3 more sources
T-cell therapies for T-cell lymphoma
Cytotherapy, 2019T-cell lymphomas represent a subpopulation of non-Hodgkin lymphomas with poor outcomes when treated with conventional chemotherapy. A variety of novel agents have been introduced as new treatment strategies either as first-line treatment or in conjunction with chemotherapy. Immunotherapy has been demonstrated to be a promising area for new therapeutics,
Keri Toner +2 more
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Science, 1987
The primary structure of T cell receptor proteins and genes is well understood. Immunologists are now trying to understand the properties of these interesting molecules. Evidence suggests that T cell αβ receptors recognize a complex of an antigen-derived peptide bound to one of the cell-surface products of the major histocompatibility complex (MHC ...
P, Marrack, J W, Kappler
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The primary structure of T cell receptor proteins and genes is well understood. Immunologists are now trying to understand the properties of these interesting molecules. Evidence suggests that T cell αβ receptors recognize a complex of an antigen-derived peptide bound to one of the cell-surface products of the major histocompatibility complex (MHC ...
P, Marrack, J W, Kappler
openaire +3 more sources
NeuroMolecular Medicine, 2005
The microvasculature of the brain region affected by a stroke assumes an inflammatory phenotype that is characterized by endothelial cell activation and barrier dysfunction and the recruitment of adherent leukocytes. Although most attention has been devoted to the possible role of neutrophils in the tissue responses to ischemic stroke there is evidence
Arumugam, Thiruma V. +2 more
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The microvasculature of the brain region affected by a stroke assumes an inflammatory phenotype that is characterized by endothelial cell activation and barrier dysfunction and the recruitment of adherent leukocytes. Although most attention has been devoted to the possible role of neutrophils in the tissue responses to ischemic stroke there is evidence
Arumugam, Thiruma V. +2 more
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T Cell Receptors and T Cell Development
1996Birds provide a valuable model system for the study of early development. Studies of immune system development and function in chickens have contributed to some of the central tenets in immunology. These include:(1) allorecognition by lymphocytes in graft-vs-host (GVH) reactions (Simonsen 1985), (2) clonal reactivity of immunocompetent lymphocytes ...
C H, Chen +6 more
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T-Cell Receptor Expression in the T-Cell Malignancies
American Journal of Clinical Pathology, 1990Twenty-eight cases with T-cell neoplasms (10 with T-cell acute lymphoblastic leukemia [T-ALL], 10 with T-lymphoblastic lymphoma, and 8 with peripheral T-cell lymphomas) and 2 cases with reactive lymph nodes were immunohistochemically stained with monoclonal antibodies beta F1, delta TCS1, and WT31; beta F1 antibody recognizes the beta-subunit of T-cell
N, Mori +4 more
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Flow Cytometry of T cells and T-cell Neoplasms
Clinics in Laboratory Medicine, 2017Flow cytometry is ideally suited for the immunophenotypic analysis of T-cell neoplasia. This article covers the spectrum of flow cytometric findings associated with frequently encountered benign and neoplastic T-cell populations and details the most common immunophenotypic features associated with specific neoplasms of both immature and mature T cells.
Jeffrey W, Craig, David M, Dorfman
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T cells and T‐cell subsets in periodontal diseases
Journal of Periodontal Research, 1989Acetone‐fixed cryostat gingival tissue sections from marginal gingivitis (MG), juvenile periodontitis (JP), adult periodontitis (AP) patients and clinically healthy subjects (H) were immunohistochemically stained with monoclonal antibodies to aid in identification and quantification of T cells and T‐cell subsets in the inflammatory infiltrates. T cells
H X, Meng, L F, Zheng
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T cell-T cell activation in multiple sclerosis
Multiple Sclerosis Journal, 1997Activated T cells are able to stimulate proliferation in resting T cells through an antigen non-specific mechanism. The in vivo usefulness of this T cell-T cell activation is unclear, but it may serve to amplify immune responses. T cell-T cell activation could be involved in the well-documented occurrence of multiple sclerosis (MS) exacerbations ...
J W, Lindsey, R H, Kerman, J S, Wolinsky
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Designer T cells by T cell receptor replacement
European Journal of Immunology, 2006AbstractT cell receptor (TCR) gene transfer is a convenient method to produce antigen‐specific T cells for adoptive therapy. However, the expression of two TCR in T cells could impair their function or cause unwanted effects by mixed TCR heterodimers. With five different TCR and four different T cells, either mouse or human, we show that some TCR are ...
Daniel, Sommermeyer +11 more
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