Results 51 to 60 of about 8,441,406 (356)

IL-4 drives exhaustion of CD8+ CART cells

Nature Communications
Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide CRISPR ...
Carli M. Stewart, Elizabeth L. Siegler, R. Leo Sakemura, Michelle J. Cox, Truc Huynh, Brooke Kimball, Long Mai, Ismail Can, Claudia Manriquez Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Ekene Ogbodo, Wazim Mohammed Ismail, Alexandre Gaspar-Maia, Justin Budka, Jenny Kim, Nathalie Scholler, Mike Mattie, Simone Filosto, Saad S. Kenderian   +20 more
doaj   +1 more source

Combination therapy with PD-1 blockade and radiofrequency ablation for recurrent hepatocellular carcinoma: a propensity score matching analysis

International Journal of Hyperthermia, 2021
Background This study aimed to evaluate whether combined therapy with PD-1 blockade (anti-PD-1) and radiofrequency ablation (RFA) is superior to RFA monotherapy for recurrent hepatocellular carcinoma (HCC).
Xiaofei Wang, Guo Liu, Shu Chen, Huaqiang Bi, Feng Xia, Kai Feng, Kuansheng Ma, Bing Ni   +7 more
doaj   +1 more source

Moving in the Dark: Enlightening the Spatial Population Ecology of European Cave Salamanders

Population Ecology, EarlyView.
We assessed individual interactions, movement ecology and activity patterns of a subterranean population of Speleomantes strinatii, applying spatial capture–recapture modeling to a photographic dataset of 104 individuals. ABSTRACT Space use and movement are fundamental aspects of organisms' ecology, mirroring individual fitness, behavior, and life ...
Giacomo Rosa, Andrea Costa, Sebastiano Salvidio   +2 more
wiley   +1 more source

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner [PDF]

, 2019
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-kappa B and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions.
Baens, Mathijs, Beyaert, Rudi, Demeyer, Annelies, Driege, Yasmine, Hochepied, Tino, Kreike, Marja, Skordos, Ioannis, Staal, Jens   +7 more
core   +2 more sources

Cell Stress and Cell Death

International Journal of Cell Biology, 2010
This special issue on Cell Stress and Cell Death is aimed at bringing together recent developments in the fields of cellular stress and cell death and, in particular, the interplay between cell stress responses and cell death. The special issue opens with a review by S. Fulda et al.
Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, Srinivasa M. Srinivasula   +4 more
openaire   +6 more sources

Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors

Population Ecology, EarlyView.
Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley   +1 more source

Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]

, 2019
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid, Couck, Liesbeth, Favoreel, Herman, Laval, Kathlyn, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien, Van Den Broeck, Wim   +7 more
core   +1 more source

Cell-to-Cell Spread of Retroviruses [PDF]

Viruses, 2010
Viruses from several families use direct cell-to-cell infection to disseminate between cells. Retroviruses are a relatively recent addition to this list, and appear to spread cell-to-cell by induction of multimolecular complexes termed virological synapses that assemble at the interface between infected and receptor-expressing target cells.
openaire   +6 more sources

An Adaptive Management Model for Brown Bears in Hokkaido: Based on Total Population and the Number of Nuisance Bears

Population Ecology, EarlyView.
Bear management changes management actions according to the horizontal axis of the population size and the vertical axis of the number of nuisance bears. Aiming for the target population size of Ntar, Actions I and II protect the bears, and Action IV reduces the population.
Hiroyuki Matsuda, Akira Maki, Tsutomu Mano, Hifumi Tsuruga, Hino Takafumi, Shinichi Horino   +5 more
wiley   +1 more source

Cell-by-Cell Deconstruction of Stem Cell Niches [PDF]

Cell Stem Cell, 2020
Single-cell sequencing approaches offer exploration of tissue architecture at unprecedented resolution. These tools are especially powerful when deconvoluting highly specialized microenvironments, such as stem cell (SC) niches. Here, we review single-cell studies that map the cellular and transcriptional makeup of stem and progenitor niches and discuss
Anastasia N. Tikhonova, Iannis Aifantis, Audrey Lasry, Rebecca Austin   +3 more
openaire   +2 more sources