Results 81 to 90 of about 8,261,953 (362)

Frequencies and TCR Repertoires of Human 2,4,6-Trinitrobenzenesulfonic Acid-specific T Cells

Frontiers in Toxicology, 2022
Allergic contact dermatitis is a widespread T cell-mediated inflammatory skin disease, but in vitro monitoring of chemical-specific T cells remains challenging.
Caterina Curato, Caterina Curato, Marina Aparicio-Soto, Marina Aparicio-Soto, Franziska Riedel, Franziska Riedel, Franziska Riedel, Ingrun Wehl, Ingrun Wehl, Alev Basaran, Alev Basaran, Amro Abbas, Amro Abbas, Amro Abbas, Hermann-Josef Thierse, Andreas Luch, Andreas Luch, Andreas Luch, Katherina Siewert, Katherina Siewert   +19 more
doaj   +1 more source

Limiting energy dissipation induces glassy kinetics in single cell high precision responses [PDF]

, 2015
Single cells often generate precise responses by involving dissipative out-of-thermodynamic equilibrium processes in signaling networks. The available free energy to fuel these processes could become limited depending on the metabolic state of an individual cell.
arxiv   +1 more source

A new homeostatic model of the T cell system [PDF]

Journal of Biological Systems, 19, 299-317, 2011, 2010
Our main tenet argues that the primary role of positive thymic selection and the resulting T cell population is the maintenance of a homeostatic equilibrium with self MHC-self peptide complexes. The homeostatic T cell repertoire can recognize infections non-specifically and this is an indirect (negative) recognition: the whole homeostatic T cell ...
arxiv   +1 more source

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy [PDF]

, 2020
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly ...
Adair, Jennifer E., DeBerg, Hannah A., Enstrom, Mark R., Gersuk, Vivian, Gottardo, Raphaël, Hanafi, Laïla-Aïcha, Hawkins, Reed, Kiem, Hans-Peter, Linsley, Peter S., Maloney, David G., Pande, Dnyanada, Riddell, Stanley R., Sheih, Alyssa, Turtle, Cameron J., Voillet, Valentin, Wohlfahrt, Martin E., Yajima, Masanao   +16 more
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment

OncoImmunology, 2020
Although anti-programmed death-1 (PD-1) treatment has shown remarkable anti-tumor efficacy, immune-related adverse events (irAEs) develop with heterogeneous clinical manifestations.
Kyung Hwan Kim, Joon Young Hur, Jinhyun Cho, Bo Mi Ku, Jiae Koh, June Young Koh, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn, Eui-Cheol Shin   +11 more
doaj   +1 more source

T cell equation as a conceptual model of T cell responses for maximizing the efficacy of cancer immunotherapy [PDF]

SOJ Immunol 5(1):1-5, 2017, 2015
Following antigen stimulation, the net outcomes of a T cell response are shaped by integrated signals from both positive co-stimulatory and negative regulatory molecules. Recently, the blockade of negative regulatory molecules (i.e. immune checkpoint signals) demonstrates therapeutic effects in treatment of human cancer, but only in a fraction of ...
arxiv   +1 more source

Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets [PDF]

, 2009
T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune
A Ashkin, A Kupfer, B Alberts, B Mickey, C Kozlowski, D Depoil, EL Botvinick, EN Cytrynbaum, F Nédélec, IA Vorobjev, IA Vorobjev, IV Maly, Ivan V. Maly, J Combs, Jason A. Papin, JM Serrador, JR Kuhn, Mun Ju Kim, S Valitutti, SW Grill, T Mitchison, T Takasone, TL Hill, W Press   +23 more
core   +6 more sources

Cell-by-cell deciphering of T cells in allergic inflammation [PDF]

Journal of Allergy and Clinical Immunology, 2019
Technical advances in single-cell RNA sequencing (scRNA-seq) render it possible to examine the transcriptomes of single cells in patients with allergic inflammation with high resolution in the context of their specific microenvironment, treatment, and disease status.
Ting Wen, Marc E. Rothenberg
openaire   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source