Results 171 to 180 of about 30,095,077 (303)

Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development. [PDF]

Aging Cell
Gensheimer J, LaGosh J, Moulton ER, Sun V, de Barros SC, Montecino-Rodriguez E, Yiu G, Yuan X, Dorshkind K, Crooks GM.   +9 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Viable <i>Gata2</i> deficient mice exhibit T cell development independent of adult definitive hematopoiesis. [PDF]

Front Immunol
Li Y, Dang S, Li J, Zhang T, Du J, Pan G, Huang K.   +6 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development. [PDF]

Immunol Cell Biol
Fulford TS, Koay HF, Grumont R, Johnson DN, Scheer S, Nel HJ, Thomas R, Mak JY, Fairlie DP, Teh CE, Gray DH, Bryant VL, Zaph C, O'Reilly LA, Gerondakis S, Godfrey DI.   +15 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [PDF]

Eur J Immunol
Ogan BM, Forstlova V, Dowling LJ, Simova M, Vicikova K, Novosadova V, Spoutil F, Cervenkova S, Procházková M, Tureckova J, Fedosieieva O, Labaj J, Nickl P, Krizova K, Prochazka J, Sedlacek R, Balounova J.   +16 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Advancing adoptive cellular immunotherapy via Notch-based ex vivo T cell development platforms. [PDF]

Biomed Pharmacother
Tuckett AZ, Zakrzewski JL.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source