Results 121 to 130 of about 1,632,256 (263)

Corrigendum to Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy

Frontiers in Immunology, 2014
Hugo Antonius Van Den Berg
doaj   +1 more source

Immunosenescent CD8 ⁺ T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension [PDF]

, 2013
Jong‐Chan Youn, Hee Tae Yu, Beom Jin Lim, Myoung Ju Koh, Jino Lee, Dong-Yeop Chang, Yoon Seok Choi, Sang‐Hak Lee, Seok‐Min Kang, Yangsoo Jang, Ook Joon Yoo, Eui‐Cheol Shin, Sungha Park   +12 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

IL-2–inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells [PDF]

Zheng Fu, Zineng Huang, Hao Xu, Qingbai Liu, Jing Li, Keqing Song, Yating Deng, Yujia Tao, Huifang Zhang, Peilong Wang, Heng Li, Sheng Yue, Aijun Zhou, Lianbin Han, Yan Fu, C Wang, Saurav Kumar Choudhary, Kaixiong Ye, Gianluca Veggiani, Zhihong Li, Avery August, Weishan Huang, Qiang Shan, Hongling Peng   +23 more
openalex   +1 more source

Engrafted maternal T cells in human severe combined immunodeficiency: Evidence for a TH2 phenotype and a potential role of apoptosis on the restriction of T-cell receptor variable β repertoire [PDF]

, 1998
Alessandro Plebani, Maddalena Stringa, Ignazia Prigione, Paola Facchetti, Fabio Ghiotto, Irma Airoldi, R. Giacchino, Emilio Cristina, Fulvio Porta, Carlo E. Grossi, Vito Pistoia   +10 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

, 1988
Allan M. Weissman, D Hou, David G. Orloff, W.S. Modi, Héctor N. Seuánez, Stephen J. O’Brien, R D Klausner   +6 more
openalex   +2 more sources

Effects of anti-IL-4 receptor monoclonal antibody onin vitroT cell cytokine levels: IL-4 production by T cells from non-atopic donors [PDF]

, 1998
Dominique Bullens, Ahmad Kasran, Xiaohui Peng, K Lorré, Jan Ceuppens   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source