Results 21 to 30 of about 2,637,595 (353)

Germline T cell receptor exchange results in physiological T cell development and function

Nature Communications, 2023
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which ...
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes   +10 more
doaj   +1 more source

Discovery of the first PD-1 ligand encoded by a pathogen

Frontiers in Immunology, 2022
Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The
Pablo Martínez-Vicente, Francesc Poblador, Judith Leitner, Domènec Farré, Peter Steinberger, Pablo Engel, Pablo Engel, Ana Angulo, Ana Angulo   +8 more
doaj   +1 more source

Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]

, 2018
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K, Kaplan, Henry J, Liang, Dongchun, O'Brien, Rebecca L, Shao, Hui, Sun, Deming, Woo, Jeong-Im   +6 more
core   +3 more sources

The human T-cell receptor

Journal of Clinical Immunology, 1985
Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to the identification of the human T-cell antigen receptor as a surface complex comprised of a clonotypic 90-kD Ti heterodimer and the invariant 20- and 25-kD T3 molecules.
Acuto, O, Fabbi, M, Bensussan, A, Milanese, C, Campen, T, Royer, H, Reinherz, E   +6 more
openaire   +4 more sources

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]

, 1989
Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette, A Townsend, B Babbitt, C DeLisi, DW Thomas, GM Keil, H Margalit, H Volkmer, HC Bodmer, JB Rothbard, JB Rothbard, Jonathan B. Rothbard, M Del Val, Matthias J. Reddehase, MBA Oldstone, MF Good, MJ Reddehase, MJ Reddehase, MJ Reddehase, MM Davis, N Shastri, P Marrack, PJ Bjorkman, PM Allen, R Shimonkevitz, RH Schwartz, RH Schwartz, RM Zinkernagel, S Buus, UH Koszinowski, Ulrich H. Koszinowski   +30 more
core   +1 more source

Cell surface receptors

Current Opinion in Structural Biology, 2000
During the past year, the database of ligand-receptor complexes has essentially doubled. These new results have immeasurably extended and expanded our view of cell surface receptor structure and function. The flood of data has revealed new models for receptor cross-linking, demonstrating the potential stringency of the extracellular requirements for ...
Deller, M, Yvonne Jones, E
openaire   +4 more sources

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Allen, R, Allen, TM, Allgaier, R, Altfeld, M, Feeney, M, Gandhi, RT, Kavanagh, DG, Lichterfeld, M, Miura, T, Moza, B, Mui, SK, Pereyra, F, Rosenberg, ES, Sivamurthy, R, Sundberg, EJ, Trocha, A, Walker, BD, Williams, KL, Yu, XG   +18 more
core   +3 more sources

The LCMV gp33-specific memory T cell repertoire narrows with age

Immunity & Ageing, 2012
Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam, Vincent Benjamin G, Krovi Harsha, Steele Shaun, Frelinger Jeffrey A   +4 more
doaj   +1 more source

Force generation upon T cell receptor engagement. [PDF]

PLoS ONE, 2011
T cells are major players of adaptive immune response in mammals. Recognition of an antigenic peptide in association with the major histocompatibility complex at the surface of an antigen presenting cell (APC) is a specific and sensitive process whose ...
Julien Husson, Karine Chemin, Armelle Bohineust, Claire Hivroz, Nelly Henry   +4 more
doaj   +1 more source

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C, Freeman, Tom, Hasegawa, Hitoshi, Herbert, Mark, McMichael, Andrew J, Willinger, Tim   +5 more
core   +1 more source