Force generation upon T cell receptor engagement. [PDF]
PLoS ONE, 2011 T cells are major players of adaptive immune response in mammals. Recognition of an antigenic peptide in association with the major histocompatibility complex at the surface of an antigen presenting cell (APC) is a specific and sensitive process whose ...
Julien Husson +4 more
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Regulation of T Cell Apoptosis via T Cell Receptors and Steroid Receptors [PDF]
STEM CELLS, 1996 Less than 5% of immature CD4/CD8 double-positive (DP) thymocytes are positively selected to survive and differentiate into single-positive CD4 and CD8 T cells, while self-reactive DP thymocytes undergo apoptosis (negative selection). Both positive and negative selection events are active processes that involve signaling through the T cell receptors ...
M, Iwata, Y, Ohoka, T, Kuwata, A, Asada
openaire +2 more sources
MAVS Is essential for primary CD4 + T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection [PDF]
, 2017 The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development.
Barrett, Alan D +11 more
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The LCMV gp33-specific memory T cell repertoire narrows with age
Immunity & Ageing, 2012 Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam +4 more
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A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]
, 1989 Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette +30 more
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Discovery of the first PD-1 ligand encoded by a pathogen
Frontiers in Immunology, 2022 Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The
Pablo Martínez-Vicente +8 more
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The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
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Drug functional remapping: a new promise for tumor immunotherapy
Frontiers in OncologyThe research and development of new anti-cancer drugs face challenges such as high costs, lengthy development cycles, and limited data on side effects.
Jiayi Dong +27 more
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T cell receptor signaling and cell immunotherapy
National Science OpenAs the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells.
Zhang Linsong +3 more
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A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families
Vaccines, 2020 Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed
Jie Wang +7 more
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