Results 21 to 30 of about 1,770,050 (315)

Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]

, 2012
T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor, Johannessen, Ingolfur, Talbot, Simon, Cheadle, Eleanor J, Crawford, Dorothy, Gilham, David, Gilham, David E, Johannessen, Ingo, Swanson, Anna   +8 more
core   +1 more source

Force generation upon T cell receptor engagement. [PDF]

PLoS ONE, 2011
T cells are major players of adaptive immune response in mammals. Recognition of an antigenic peptide in association with the major histocompatibility complex at the surface of an antigen presenting cell (APC) is a specific and sensitive process whose ...
Julien Husson, Karine Chemin, Armelle Bohineust, Claire Hivroz, Nelly Henry   +4 more
doaj   +1 more source

Regulation of T Cell Apoptosis via T Cell Receptors and Steroid Receptors [PDF]

STEM CELLS, 1996
Less than 5% of immature CD4/CD8 double-positive (DP) thymocytes are positively selected to survive and differentiate into single-positive CD4 and CD8 T cells, while self-reactive DP thymocytes undergo apoptosis (negative selection). Both positive and negative selection events are active processes that involve signaling through the T cell receptors ...
M, Iwata, Y, Ohoka, T, Kuwata, A, Asada
openaire   +2 more sources

The LCMV gp33-specific memory T cell repertoire narrows with age

Immunity & Ageing, 2012
Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam, Vincent Benjamin G, Krovi Harsha, Steele Shaun, Frelinger Jeffrey A   +4 more
doaj   +1 more source

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R., Burroughs, N.J., Burroughs, Nigel John, Wedagedera, J. R.   +3 more
core   +1 more source

CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma. [PDF]

, 2012
The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we
Jellbauer, Stefan, Hetrodt, Justin H., Justin H Hetrodt, Rüssmann, Holger, Stefan Jellbauer, Klaus Panthel, Holger Rüssmann, Panthel, Klaus   +7 more
core   +1 more source

Drug functional remapping: a new promise for tumor immunotherapy

Frontiers in Oncology
The research and development of new anti-cancer drugs face challenges such as high costs, lengthy development cycles, and limited data on side effects.
Jiayi Dong, Jiayi Dong, Jiayi Dong, Ting Su, Ting Su, Ting Su, Ting Su, Jiexiong Wu, Yu Xiang, Yu Xiang, Yu Xiang, Yu Xiang, Minghan Song, Minghan Song, Minghan Song, Canfeng He, Canfeng He, Canfeng He, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Yubin Yang, Yubin Yang, Size Chen, Size Chen, Size Chen, Size Chen   +27 more
doaj   +1 more source

T cell receptor signaling and cell immunotherapy

National Science Open
As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells.
Zhang Linsong, Xu Xinyi, Shi Xiaoshan, Xu Chenqi   +3 more
doaj   +1 more source

A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families

Vaccines, 2020
Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed
Jie Wang, Katarzyna Urbanska, Prannda Sharma, Reza Nejati, Lauren Shaw, Megan S. Lim, Stephen J. Schuster, Daniel J. Powell Jr.   +7 more
doaj   +1 more source

The human T-cell receptor

Journal of Clinical Immunology, 1985
Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to the identification of the human T-cell antigen receptor as a surface complex comprised of a clonotypic 90-kD Ti heterodimer and the invariant 20- and 25-kD T3 molecules.
Acuto, O, Fabbi, M, Bensussan, A, Milanese, C, Campen, T, Royer, H, Reinherz, E   +6 more
openaire   +3 more sources