Results 71 to 80 of about 2,637,595 (353)
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen
Nature CommunicationsT cell receptor-engineered T cells (TCR-T) could be advantageous in glioblastoma by allowing safe and ubiquitous targeting of the glioblastoma-derived peptidome.
Yu-Chan Chih +28 more
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Crossreactivity of the T-cell receptor [PDF]
Immunology Today, 1998 In this issue of Immunology Today, Don Mason argues that T cells should be highly degenerate in order to allow an immune response against any T-cell epitope. Because the number of possible epitopes is indeed much larger than the number of T-cell clonotypes in any immune system, we fully agree that each clonotype should recognize many epitopes ...
Borghans, J.A.M., Boer, R.J. de
openaire +3 more sources
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Chimeric Antigen Receptor-T Cell Therapy
HemaSphere, 2018 . Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR.
Jochen Buechner +4 more
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FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Genesis of theαβT-cell receptor [PDF]
PLOS Computational Biology, 2018 The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, calledαandβ, to recognize pathogens. Using results of high throughput sequencing and computational chain-pairing experiments of human TCR repertoires, we quantitively characterize theαβgeneration process.
Thierry Mora +4 more
openaire +8 more sources
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Novel chimeric antigen receptor T cells based on T-cell receptor-like antibodies
Blood Science, 2019 . The need for novel therapeutics against human cancers such as leukemias and solid tumors is well recognized. Human T cells are poised to make a fundamental change in the therapeutic approach. T-cell interaction with a tumor cell is a critical event and
Qi Zhao
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FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
T cell receptor-engineered T cells for leukemia immunotherapy
Cancer Cell International, 2019 At present, refractory and relapse are major issues for leukemia therapy and a major cause of allogeneic hematopoietic stem cell transplant failure. Over the last decade, many studies have demonstrated that adoptive cancer antigen-specific T cell therapy
Yikai Zhang, Yangqiu Li
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