Results 121 to 130 of about 56,239 (298)

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Identification of SARS-CoV-2-specific T cell and its receptor

Journal of Hematology & Oncology
The T-cell receptor (TCR) repertoires exhibits distinct signatures associated with COVID-19 severity. However, the precise identification of vaccine-induced SARS-CoV-2-specific TCRs and T-cell immunity mechanisms are unknown.
Qian Zhang, Qing Liang, Rui Zhang, Nan Wang, Xu Xiao, Jiahao Shao, Kejia Wang   +6 more
doaj   +1 more source

Characteristics of T cell receptor repertoires of patients with acute myocardial infarction through high-throughput sequencing

Journal of Translational Medicine, 2019
Background T cells are key regulators of immunity and one of the cells recruited in atherosclerosis and participated in various stages of the development of atherosclerosis.
Zhixiong Zhong, Heming Wu, Qifeng Zhang, Wei Zhong, Pingsen Zhao   +4 more
doaj   +1 more source

Enriching and Characterizing T Cell Repertoires from 3' Barcoded Single-Cell Whole Transcriptome Amplification Products. [PDF]

Methods Mol Biol, 2022
Jivanjee T, Ibrahim S, Nyquist SK, Gatter GJ, Bromley JD, Jaiswal S, Berger B, Behar SM, Love JC, Shalek AK.   +9 more
europepmc   +1 more source

Integrated control of vector-borne diseases of livestock--pyrethroids: panacea or poison?

, 2003
Tick- and tsetse-borne diseases cost Africa approximately US$4-5 billion per year in livestock production-associated losses. The use of pyrethroid-treated cattle to control ticks and tsetse promises to be an increasingly important tool to counter this ...
Coleman, Paul G, Eisler, Mark C, Machila, Noreen, Morton, John F, Torr, Stephen J   +4 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Selection of the lamprey VLRC antigen receptor repertoire

, 2014
The alternative adaptive immune system of jawless vertebrates is based on different isotypes of variable lymphocyte receptors (VLRs) that are composed of leucine-rich repeats (LRRs) and expressed by distinct B- and T-like lymphocyte lineages.
Aravind, L., Boehm, T., Cooper, M., Gao, M., Hirano, M., Holland, S., Iyer, L., Luo, M., Mariuzza, R., Schorpp, M.   +9 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis

Frontiers in Immunology
BackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du, Yunyun Deng, Ling Deng, Boping Du, Aiying Xing, Hong Tao, Hua Li, Li Xie, Xinyong Zhang, Tao Sun, Tao Sun, Hao Li, Hao Li   +12 more
doaj   +1 more source

The T Cell Repertoires from Nickel Sensitized Joint Implant Failure Patients. [PDF]

Int J Mol Sci, 2021
Chen L, Zhang Y, Pacheco K, Dai S.
europepmc   +1 more source