Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation
Advanced Science, EarlyView.This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar +10 more
wiley +1 more source
RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma. [PDF]
NPJ Genom Med, 2019 Farmanbar A, Kneller R, Firouzi S.
europepmc +1 more source
Advanced Science, EarlyView.Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao +25 more
wiley +1 more source
Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors. [PDF]
Proc Natl Acad Sci U S A, 2019 Hassler T +9 more
europepmc +1 more source
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu +7 more
wiley +1 more source
TCR Analyses of Two Vast and Shared Melanoma Antigen-Specific T Cell Repertoires: Common and Specific Features. [PDF]
Front Immunol, 2018 Simon S +9 more
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai +10 more
wiley +1 more source
Circulating CD8+ T-cell repertoires reveal the biological characteristics of tumors and clinical responses to chemotherapy in breast cancer patients. [PDF]
Cancer Immunol Immunother, 2018 Lin KR +10 more
europepmc +1 more source
Material‐Based Intelligence: Autonomous Adaptation and Embodied Computation in Physical Substrates
Advanced Intelligent Systems, EarlyView.This perspective formulates a unifying framework for Material‐Based Intelligence (MBI), defining the physical requirements for materials to achieve embodied action, active memory and embodied information processing through intrinsic nonequilibrium dynamics. The design of intelligent materials often draws parallels with the complex adaptive behaviors of
Vladimir A. Baulin +4 more
wiley +1 more source
Insights into immune system development and function from mouse T-cell repertoires. [PDF]
Proc Natl Acad Sci U S A, 2017 Sethna Z +6 more
europepmc +1 more source