Results 101 to 110 of about 41,042,307 (363)

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant

OncoImmunology, 2017
Among reported advantages of umbilical cord blood (CB) in transplantation is lower leukemia relapse probability. Underlying cellular mechanisms of graft-vs.-leukemia (GVL) are thought to include a prominent role for T cells.
Sami B. Kanaan, Hilary S. Gammill, Whitney E. Harrington, Stephen C. De Rosa, Philip A. Stevenson, Alexandra M. Forsyth, Judy Allen, Emma Cousin, Koen van Besien, Colleen S. Delaney, J. Lee Nelson   +10 more
doaj   +1 more source

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients experience treatment resistance.
Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W. Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P.E. Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esther C.W. Breij, Maria Jure-Kunkel, Ugur Sahin   +20 more
doaj   +1 more source

CAR-T Cell Therapy for T-Cell Malignancies.

Mediterranean journal of hematology and infectious diseases
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially expressed on malignant B-cells or plasma cells have been introduced in the therapy of B-cell lymphomas,
Ugo Testa, Patrizia Chiusolo, Elvira Pelosi, Germana Castelli, Giuseppe Leone   +4 more
openaire   +3 more sources

Regulatory T-Cell Depletion in Angioimmunoblastic T-Cell Lymphoma [PDF]

The American Journal of Pathology, 2010
Angioimmunoblastic T-cell lymphoma (AITL) is the most frequent nodal T-cell lymphoma and is characterized by a polymorphic lymph node infiltrate, various dysimmune disorders, and a poor prognosis. Regulatory T-cells (Treg) play an emerging role in the prognosis of non-Hodgkin B-cell lymphoma and mediate significant autoreactive T-cell suppression.
Bruneau, Julien, Canioni, D., Renand, A., Marafioti, T., Paterson, J.C., Martin-Garcia, N., Gaulard, P., Delfau, M.H., Hermine, O., Macintyre, E., Brousse, N., Asnafi, V.   +11 more
openaire   +3 more sources

Gad65 is recognized by t-cells, but not by antibodies from nod-mice [PDF]

, 1994
Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice,
Seißler, Jochen, Bieg, Sabine, Herberg, Lieselotte, Northemann, Wolfgang, Scherbaum, Werner A.   +4 more
core   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

The Network of miRNA–mRNA Interactions in Circulating T Cells of Patients Following Major Trauma – A Pilot Study

Journal of Inflammation Research, 2022
Cheng-Shyuan Rau1 *, Pao-Jen Kuo2 *, Hui-Ping Lin,2 Chia-Jung Wu,2 Yi-Chan Wu,2 Peng-Chen Chien,2 Ting-Min Hsieh,3 Hang-Tsung Liu,3 Chun-Ying Huang,3 Ching-Hua Hsieh2 1Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang ...
Rau CS, Kuo PJ, Lin HP, Wu CJ, Wu YC, Chien PC, Hsieh TM, Liu HT, Huang CY, Hsieh CH   +9 more
doaj  

Complex analysis of correlation interrelations between indicators of humoral and cellular immunity in persons vaccinated against plague

Инфекция и иммунитет, 2019
At present, the search for biomarkers, which indicate the presence of tense antiplague immunity, is continuing. The aim of the study was to determine the parameters of cellular and humoral immunity in persons vaccinated with the plague vaccine according ...
S. N. Klyueva, S. A. Bugorkova, A. Y. Goncharova, A. L. Kravtsov, O. M. Kudryavtseva, D. N. Sandzhiev, S. V. Konusheva, S. P. Savchenko, B. A. Khasykova, B. L. Agapov, S. A. Shcherbakova   +10 more
doaj   +1 more source

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Science Translational Medicine, 2017
A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance. Speeding toward CAR T cell therapy for glioblastoma Chimeric antigen receptor (CAR) T cells have been successfully implemented ...
D. O'Rourke, M. Nasrallah, A. Desai, J. Melenhorst, K. Mansfield, J. Morrissette, M. Martinez-Lage, S. Brem, E. Maloney, Angela Shen, R. Isaacs, S. Mohan, G. Plesa, S. Lacey, J. Navenot, Zhaohui Zheng, B. Levine, H. Okada, C. June, J. Brogdon, Marcela V. Maus   +20 more
semanticscholar   +1 more source