Results 241 to 250 of about 41,042,307 (363)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

T cells are blind to the dark mechanics of tumors.

Trends Open
Fritzsche M, Kruse K.
europepmc   +1 more source

FoxP3+ Regulatory T-Cells in Canine Cutaneous Lymphoma and Their Role in Immune Modulation. [PDF]

In Vivo
Semolin LMS, Anai LA, Jark PC, Munhoz TD, Cruvinel GG, Bitencourt RC, DA Rosa Sobreira MF, Camplesi AC, Leitão JR, Santana AE, Alves CEF.   +10 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Research advances in the interplay between ferroptosis and T cells in the tumor microenvironment (Review). [PDF]

Mol Med Rep
Tang S, Xu W, Li Y, Liu C, Liu W, Liang R, Liao Q, Sun H, Wang Z, Shi L, Liu Q, Liu H.   +11 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

CAR T cells for HLA desensitization: a new era in kidney transplantation. [PDF]

Signal Transduct Target Ther
Mertens PR, Feist E, Mougiakakos D.
europepmc   +1 more source

Regulatory T cells in cancer immunotherapy

Cell Research, 2016
A. Tanaka, S. Sakaguchi
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source