Results 281 to 290 of about 41,042,307 (363)

Exploring the functions of NKG7 in CD4+ and CD8+ T cells during malaria. [PDF]

PLoS Pathog
Frame TC, de Labastida Rivera F, Dooley NL, Engel JA, Na J, Wang Y, Bukali L, Ng SS, Bunn PT, Beattie L, Hartel G, William T, Grigg MJ, Anstey NM, McCarthy JS, Barber BE, Boyle MJ, Engwerda CR.   +17 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Multifaceted mechanisms of unconventional T cells in ischemia-reperfusion injury. [PDF]

Front Immunol
Li J, Lin P, Yuan M, Wang Y, Liu H, Jia R, Fan J, Liang L, Han P, Guo Q, He Y.   +10 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Perinatal γδ T cells: between invariance and diversity. [PDF]

Front Immunol
Köhn RM, Prinz I.
europepmc   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells. [PDF]

Chemistry
Mak JYW, Hoang HN, Awad W, Lim XY, Laurie DD, Rivero RJD, McCluskey J, Corbett AJ, Rossjohn J, Fairlie DP.   +9 more
europepmc   +1 more source

Tacrolimus-resistant regulatory T cells: Combining the best of both worlds? [PDF]

Mol Ther Adv
Kuypers D.
europepmc   +1 more source