B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes
Frontiers in Immunology, 2019 Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and the 116C-NOD mice.
Leire Egia-Mendikute +14 more
doaj +1 more source
Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus [PDF]
, 1975 VARIOUS virus infections lead to the formation of cytotoxic lymphocytes (CL), which are capable of killing virus-infected target cells1−4. Specific lysis of target cells infected with 51Cr-labelled vaccinia virus could be observed when investigating the ...
GJ Hämmerling +13 more
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Near-infrared imaging of adoptive immune cell therapy in breast cancer model using cell membrane labeling. [PDF]
PLoS ONE, 2014 The overall objective of this study is to non-invasively image and assess tumor targeting and retention of directly labeled T-lymphocytes following their adoptive transfer in mice.
Fatma M Youniss +8 more
doaj +1 more source
HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]
, 2009 Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
Miura, T. +10 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
T cells responding to Trypanosoma cruzi detected by membrane TNF‐α and CD154 in chagasic patients
Immunity, Inflammation and Disease, 2018 Introduction Chagas disease is a parasitic infection whose pathogenesis is related to parasite persistence and a dysfunctional cellular immune response.
Juan G. Ripoll +7 more
doaj +1 more source
Innate-like T lymphocytes in chronic liver disease
Frontiers in Immunology, 2023 In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis.
Maria Papanastasatou +1 more
doaj +1 more source
Characterization of serotonin transporter expression in human T lymphocytes [PDF]
, 2014 Serotonin transporter (SERT) expression has been demonstrated in human lymphocytes, including B lymphocytes, NK cells and other immune cells. However, discussion remains on whether human T lymphocytes express SERT. Given the potentially important role of
De Spiegelaere, Ward +5 more
core
Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]
, 1975 Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Alkan +36 more
core +1 more source