Results 1 to 10 of about 5,743,561 (311)

Non-viral transfection technologies for next-generation therapeutic T cell engineering [PDF]

Biotechnology Advances, 2021
Genetically engineered T cells have sparked interest in advanced cancer treatment, reaching a milestone in 2017 with two FDA-approvals for CD19-directed chimeric antigen receptor (CAR) T cell therapeutics. It is becoming clear that the next generation of CAR T cell therapies will demand more complex engineering strategies and combinations thereof ...
Raes, Laurens, De Smedt, Stefaan C., Raemdonck, Koen, Braeckmans, Kevin   +3 more
openaire   +2 more sources

Clostridium difficile Infections in an Emergency Surgical Unit from North-East Romania

Medicina, 2023
Background and Objectives: Colitis with Clostridium difficile is an important health problem that occurs with an intensity that varies between mild and severe. Surgical interventions are required only in fulminant forms.
Bogdan Mihnea Ciuntu, Gheorghe G. Balan, Mihaela Buna-Arvinte, Irina Mihaela Abdulan, Adelina Papancea, Ștefan Lucian Toma, Bogdan Veliceasa, Oana Viola Bădulescu, Gabriela Ghiga, Ana Maria Fătu, Mihai Bogdan Vascu, Antonia Moldovanu, Dan Vintilă, Alin Mihai Vasilescu   +13 more
doaj   +1 more source

Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Metformin Hydrochloride in Tablet Dosage Forms by HPLC

Pharmaceutics, 2022
The current studies entail quality by design (QbD)-enabled development of a simple, rapid, precise, accurate, and cost-effective high-performance liquid chromatographic method for estimation of metformin hydrochloride (M-HCl). Design of experiments (DoE)
Mousa Sha’at, Adrian Florin Spac, Iulian Stoleriu, Alexandra Bujor, Monica Stamate Cretan, Mihaela Hartan, Lacramioara Ochiuz   +6 more
doaj   +1 more source

T cell fate mapping and lineage tracing technologies probing clonal aspects underlying the generation of CD8 T cell subsets [PDF]

Scandinavian Journal of Immunology, 2020
AbstractT cells responding to acute infections generally provide two key functions to protect the host: (1) active contribution to pathogen elimination and (2) providing long‐lived cells that are poised to rapidly respond to renewed infection, thus ensuring long‐lasting protection against the particular pathogen.
Shaima Al Khabouri, Carmen Gerlach
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Next-Generation Sequencing Technologies for Early-Stage Cutaneous T-Cell Lymphoma [PDF]

Frontiers in Medicine, 2019
The diagnosis of early stage cutaneous T-cell lymphoma is often difficult, particularly in mycosis fungoides (MF), because the clinical presentation, histological findings, and laboratory findings of MF resemble those of inflammatory skin diseases such as atopic dermatitis, psoriasis, and parapsoriasis en plaque.
Kazuyasu Fujii, Takuro Kanekura
openaire   +3 more sources

Research on the general technical standards of the gasoline vapor recovery unit set [PDF]

E3S Web of Conferences, 2019
Along with the increasingly strict environmental regulation and the willingness to rapidly promote gasoline vapor recovery management, the development of technology and equipment for gasoline vapor recovery industry grows faster, and the demand for ...
Huang Jin, Zhang Bingquan, Huang Weiqiu, Zhu Zhiping, Tao Feng, Wang Quanzhan, Huang Zhaohui, Zhu Jianjun, Zhang Xiaoxin, Zhang Lin   +9 more
doaj   +1 more source

Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer [PDF]

Briefings in Functional Genomics, 2018
Next-generation sequencing has produced a large quantity of DNA or RNA sequences related to the processes occurring within tumors and their microenvironment in a reasonable time and cost. These data have been used to guide the identification of neoantigens and to determine their specific T-cell receptors.
Qinan, Yin, Jiaxing, Tang, Xuekai, Zhu
openaire   +2 more sources

Adapter CAR T Cell Therapy for the Treatment of B-Lineage Lymphomas

Biomedicines, 2022
CD19CAR T cells facilitate a transformational treatment in various relapsed and refractory aggressive B-lineage cancers. In general, encouraging response rates have been observed in B-lineage-derived non-Hodgkin’s lymphomas treated with CD19CAR T cells ...
Daniel Atar, Anna-Sophia Mast, Sophia Scheuermann, Lara Ruoff, Christian Martin Seitz, Patrick Schlegel   +5 more
doaj   +1 more source

Persepsi peternak tentang teknologi asap cair (liquid smoke) tempurung kelapa di kelompok ternak satwa mandiri Kabupaten Kediri

AGROMIX, 2021
This study aims to (1) determine the perceptions of farmers about coconut shell liquid smoke technology and (2) determine the factors that influence it. The research method used a descriptive quantitative approach with a survey method.
Yunita Ninsi Saputri, Wahyu Windari, Nurlaili Nurlaili   +2 more
doaj   +1 more source

Trust-Based Determinants of Future Intention to Use Technology

Foresight and STI Governance, 2020
It is widely recognized that one of the factors determining current and future socioeconomic development is the level of digitalization shaping a new type of society — the information society.
Joanna Ejdys
doaj   +1 more source