Results 51 to 60 of about 7,267 (291)

A Mathematical Approach to Consider Solid Compressibility in the Compression of Pharmaceutical Powders

Pharmaceutics, 2019
In-die compression analysis is an effective method for the characterization of powder compressibility. However, physically unreasonable apparent solid fractions above one or apparent in-die porosities below zero are often calculated for higher ...
Isabell Wünsch, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade   +4 more
doaj   +1 more source

Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability [PDF]

, 2013
YesIn order to investigate the effect of using different solid state forms and specific surface area (TBET) of active pharmaceutical ingredients on tabletability and dissolution performance, the mono- and dihydrated crystalline forms of ...
Abdul Jaleel O. W., Anne Marie Healy, Augsburger L. L., Busignies V., Cobby J., Corrigan O. I., Debnath S., Di Martino P., Es-Saheb M. H. H., Fichtner F., Haque K., Joiris E., Krzysztof J. Paluch, Lidia Tajber, Maggi L., Ogáin O. N., Owen I. Corrigan, Paluch K. J., Paluch K. J., Paluch K. J., Paluch K. J., Paluch K. J., Pande G. S., Pitt K. G., Qiu Y., Saleki-Gerhardt A., Sebhatu T., Sun C. C., Sun C. C., Trasi N. S., Westermarck S.   +30 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Impact of blend properties on die filling during tableting [PDF]

, 2018
Based on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying paddle speed and turret speed.
De Beer, Thomas, Dhondt, Jens, Di Pretoro, G, Grymonpré, Wouter, Pandelaere, Kenny, Remon, Jean Paul, Van Snick, Bernd, Vanhoorne, Valérie, Vervaet, Chris   +8 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fast disintegrating crystalline solid dispersions of simvastatin for incorporation into orodispersible tablets [PDF]

, 2014
Aim : Spray dried solid dispersion (SDP) of crystalline simvastatin (SIM) in a fast disintegrating matrix of superdisintegrants was studied as a method to enhance SIM dispersibility, rheology, compactibility and compressibility for incorporation into ...
Ambike, Broadhead, Chowdary, De, Doelker, Frizon, Fu, Goddeeris, Gonnissen, Joiris, Jun, Kang, Margulis-Goshen, Moneghini, Mukharya, Pabari, Pabari, Patel, Puttipipatkhachorn, Ramtoola, Rytting, Sareen, Sharma, Shi, Simões, Whiteman, Yang, Yen, Yoshinari, Yu, Zimper   +30 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Compaction Behavior of Isomalt after Roll Compaction

Pharmaceutics, 2012
The suitability of the new isomalt grade galenIQ™ 801 for dry granulation and following tableting is evaluated in this study. Isomalt alone, as well as a blend of equal parts with dibasic calcium phosphate, is roll compacted and tableted ...
Peter Kleinebudde, Johanna Mosig, Julian Quodbach   +2 more
doaj   +1 more source

Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug [PDF]

, 2015
The aim of this work was to design and evaluate effervescent floating gastro-retentive drug delivery matrix tablets with sustained-release behavior using a binary mixture of hydroxyethyl cellulose and sodium alginate.
Abdel Rahim, S., Carter, Paul, Elkordy, Amal   +2 more
core   +2 more sources

Tablet Splitting: Influence of Technique and Tablet Format

, 2022
Tablet splitting is a commonly used technique to obtain half of the dose or to facilitate tablet intake. However, there is a risk of not obtaining the correct dose and the efficacy depends on factors such as splitting method and tablet characteristics.
Alexandre, Ana, Ferreira, Sónia, Jesus, Ângelo   +2 more
openaire   +2 more sources