Results 31 to 40 of about 2,240 (251)

How spherical crystallization improves direct tableting properties: a review [PDF]

Advanced Pharmaceutical Bulletin, 2012
Direct tableting has been renewed as a preferable process by simply mixing and compressing powder to save time and cost in comparison with granule tableting.
Maryam Maghsoodi
doaj  

The Challenge of Die Filling in Rotary Presses—A Systematic Study of Material Properties and Process Parameters

Pharmaceutics, 2020
For the efficient and safe production of pharmaceutical tablets, a deep process understanding is of high importance. An essential process step during tableting is the die filling, as it is responsible for a consistent tablet weight and drug content ...
Ann Kathrin Schomberg, Arno Kwade, Jan Henrik Finke   +2 more
doaj   +1 more source

Finite Element Analysis and Modeling in Pharmaceutical Tableting

Pharmaceutics, 2022
Finite element analysis (FEA) is a computational method providing numerical solutions and mathematical modeling of complex physical phenomena that evolve during compression tableting of pharmaceutical powders. Since the early 2000s, FEA has been utilized
Ioannis Partheniadis, Vasiliki Terzi, Ioannis Nikolakakis   +2 more
doaj   +1 more source

Partial Least Squares Regression-Based Robust Forward Control of the Tableting Process

Pharmaceutics, 2020
In this study, we established a robust feed-forward control model for the tableting process by partial least squares regression using the near-infrared (NIR) spectra and physical attributes of the granules to be compressed.
Yusuke Hattori, Miki Naganuma, Makoto Otsuka   +2 more
doaj   +1 more source

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients

Pharmaceutics, 2021
Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms.
Jelena Djuris, Slobodanka Cirin-Varadjan, Ivana Aleksic, Mihal Djuris, Sandra Cvijic, Svetlana Ibric   +5 more
doaj   +1 more source

Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level

Pharmaceutics, 2018
This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets.
Sushma V. Lute, Ranjit M. Dhenge, Agba D. Salman   +2 more
doaj   +1 more source

Effect of Compaction Pressure on the Enzymatic Activity of Pancreatin in Directly Compressible Formulations

Pharmaceutics, 2023
Tableting of biomolecules is a challenging formulation phase due to their sensitivity to various process parameters, such as compression pressure, process dynamics, or the temperature generated.
Daniel Zakowiecki, Peter Edinger, Tobias Hess, Jadwiga Paszkowska, Marcela Staniszewska, Svitlana Romanova, Grzegorz Garbacz   +6 more
doaj   +1 more source

Design of Agglomerated Crystals of Ibuprofen During Crystallization: Influence of Surfactant [PDF]

Iranian Journal of Basic Medical Sciences, 2011
Objective(s)Ibuprofen is a problematic drug in tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surface.
Maryam Maghsoodi, Leila Barghi
doaj  

Twin Screw Granulation: Effects of Properties of Primary Powders

Pharmaceutics, 2018
Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced ...
Sushma V. Lute, Ranjit M. Dhenge, Agba D. Salman   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source