Results 41 to 50 of about 7,267 (291)

Finite Element Analysis and Modeling in Pharmaceutical Tableting

Pharmaceutics, 2022
Finite element analysis (FEA) is a computational method providing numerical solutions and mathematical modeling of complex physical phenomena that evolve during compression tableting of pharmaceutical powders. Since the early 2000s, FEA has been utilized
Ioannis Partheniadis, Vasiliki Terzi, Ioannis Nikolakakis   +2 more
doaj   +1 more source

Partial Least Squares Regression-Based Robust Forward Control of the Tableting Process

Pharmaceutics, 2020
In this study, we established a robust feed-forward control model for the tableting process by partial least squares regression using the near-infrared (NIR) spectra and physical attributes of the granules to be compressed.
Yusuke Hattori, Miki Naganuma, Makoto Otsuka   +2 more
doaj   +1 more source

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients

Pharmaceutics, 2021
Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms.
Jelena Djuris, Slobodanka Cirin-Varadjan, Ivana Aleksic, Mihal Djuris, Sandra Cvijic, Svetlana Ibric   +5 more
doaj   +1 more source

Twin Screw Granulation: An Investigation of the Effect of Barrel Fill Level

Pharmaceutics, 2018
This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets.
Sushma V. Lute, Ranjit M. Dhenge, Agba D. Salman   +2 more
doaj   +1 more source

Effect of Compaction Pressure on the Enzymatic Activity of Pancreatin in Directly Compressible Formulations

Pharmaceutics, 2023
Tableting of biomolecules is a challenging formulation phase due to their sensitivity to various process parameters, such as compression pressure, process dynamics, or the temperature generated.
Daniel Zakowiecki, Peter Edinger, Tobias Hess, Jadwiga Paszkowska, Marcela Staniszewska, Svitlana Romanova, Grzegorz Garbacz   +6 more
doaj   +1 more source

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets [PDF]

, 2017
The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets.
Chougule, Mahavir B., Dave, Vivek S, Haware, Rahul V., Shahin, Hend I., Youngren-Ortiz, Susanne R.   +4 more
core   +2 more sources

On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient [PDF]

, 2017
The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation ...
Bawuah, Prince, Gane, Patrick, Ketolainen, Jarkko, Markl, Daniel, Peiponen, Kai Erik, Ridgway, Cathy, Zeitler, J. Axel   +6 more
core   +1 more source

Twin Screw Granulation: Effects of Properties of Primary Powders

Pharmaceutics, 2018
Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced ...
Sushma V. Lute, Ranjit M. Dhenge, Agba D. Salman   +2 more
doaj   +1 more source

The influence of fillers on theophylline release from clay matrices [PDF]

, 2015
: The objectives of this study were to investigate the suitability of magnesium aluminium silicate (MAS) (Veegum®) to control drug release of a model drug, theophylline, from tablet matrices.
Adebisi, Adeola O., Asare-Addo, Kofi, Conway, Barbara R.   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source