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Rational Function-Based Approach for Integrating Tableting Reduced-Order Models with Upstream Unit Operations: Dry Granulation Case Study [PDF]

open access: yesPharmaceuticals
We present a systematic and automatic approach for integrating tableting reduced-order models with upstream unit operations. The approach not only identifies the upstream critical material attributes and process parameters that describe the coupling to ...
Sunidhi Bachawala   +5 more
doaj   +2 more sources

Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica [PDF]

open access: yesPharmaceutics, 2023
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging.
Majed Alrobaian   +3 more
doaj   +2 more sources

Pharmaceutical development of tablets based on cryolyophilized porcine skin [PDF]

open access: yesPharmaceutical Science Advances
Among natural sources of animal origin, the most similar to human in composition is porcine skin. Crushed cryolyophilized xenoderm of porcine skin from 1st layer is used for preparation a dietary supplement Xenoderm in the form of powder, capsules and ...
Oksana Panysheva
doaj   +2 more sources

Systematic investigation of the impact of screw elements in continuous wet granulation [PDF]

open access: yesInternational Journal of Pharmaceutics: X
Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling.
Katharina Kiricenko   +2 more
doaj   +2 more sources

Minitablets as a dosage form convenient for pediatric and geriatric patients [PDF]

open access: yesFarmacja Polska, 2021
The individualization of pharmacotherapy including the age and health condition of the patient is a recent trend determining directions of pharmaceutical technology development.
Witold Brniak   +2 more
doaj   +1 more source

Effect of Moisture of Pharmaceutical Material MCC Avicel PH102 and Tablet Diameter on the Compression Process and Tablet Strength

open access: yesJournal of Mechanical Engineering, 2022
This paper focuses on the effect of moisture of powder material on the process of tablet compression and on tablet mechanical strength. The powder used in the experiments was Avicel PH102 microcrystalline cellulose, as it is the most widely used ...
Guštafík Adam   +4 more
doaj   +1 more source

Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression

open access: yesFuture Journal of Pharmaceutical Sciences, 2020
Background Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of ...
Fatima Haruna   +4 more
doaj   +1 more source

Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression

open access: yesPharmaceutics, 2021
In pharmaceutical manufacturing, the utmost aim is reliably producing high quality products. Simulation approaches allow virtual experiments of processes in the planning phase and the implementation of digital twins in operation.
Niels Lasse Martin   +5 more
doaj   +1 more source

Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry

open access: yesApplied Sciences, 2022
Following the paradigm shift in the pharmaceutical industry from batch to continuous production, additional instrumentation and revision of control strategies to optimize material flow throughout the downstream processes are required.
Mihaela Ghita   +4 more
doaj   +1 more source

Moisture Behavior of Pharmaceutical Powder during the Tableting Process

open access: yesPharmaceutics, 2023
The moisture content of pharmaceutical powder is a key parameter contributing to tablet sticking during the tableting process. This study investigates powder moisture behavior during the compaction phase of the tableting process.
Komlan Koumbogle   +3 more
doaj   +1 more source

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