Results 121 to 130 of about 157,199 (404)

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Genetic Polymorphisms Affecting Tacrolimus Metabolism and the Relationship to Post-Transplant Outcomes in Kidney Transplant Recipients

Pharmacogenomics and Personalized Medicine, 2021
Fang Cheng,1,2 Qiang Li,1,2 Jinglin Wang,1,2 Min Hu,1,2 Fang Zeng,1,2 Zhendi Wang,3 Yu Zhang1,2 1Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China ...
Cheng F, Li Q, Wang J, Hu M, Zeng F, Wang Z, Zhang Y   +6 more
doaj  

Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury

Scientific Reports, 2019
We previously reported that oxidative stress induced by long-term tacrolimus treatment impairs mitochondrial function in pancreatic beta cells. In this study, we aimed to investigate the therapeutic potential of coenzyme Q10, which is known to be a ...
K. Luo, Ji Hyun Yu, Yi Quan, Y. Shin, K. Lee, H. Kim, E. Ko, B. Chung, S. Lim, Chul-woo Yang   +9 more
semanticscholar   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Pregnancy after liver transplantation under tacrolimus [PDF]

, 1997
Background. The maternal and fetal risk of pregnancy after organ transplantation under tacrolimus has not been reported. This was prospectively studied in 27 pregnancies by 21 female liver recipients who were treated with tacrolimus before and throughout
Armenti, Ashok Jain, Bourget, Bourget, Bumgardner, Davison, Fung, Grenier, Guignard, Hamill, J. Carlton Gartner, Jackie Lever, Jain, John J. Fung, Klintmalm, Laifer, Lubchenco, McCauley, Metha, Penn, Radomski, Radomski, Raman Venkataramanan, Satlin, Scantlebury, Shaheen, Starzl, Starzl, The, The European, Thomas E. Starzl, Todo, Venkataramanan, Vijay Warty, Vijayan Balan, Warty, Winkler   +36 more
core   +1 more source

Application of Machine-Learning Models to Predict Tacrolimus Stable Dose in Renal Transplant Recipients

Scientific Reports, 2017
Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) and eight machine learning techniques in pharmacogenetic algorithm-based prediction of ...
Jie Tang, Rong Liu, Yueli Zhang, Mou-Ze Liu, Yong-fang Hu, Ming-jie Shao, Li-jun Zhu, H. Xin, G. Feng, W. Shang, Xiang-guang Meng, Li-Rong Zhang, Y. Ming, Wei Zhang   +13 more
semanticscholar   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients [PDF]

, 1999
Objective: The effect of donor bone marrow was evaluated for its potentially favorable effect in the authors' simultaneous pancreas/kidney transplant program.
Abdul S. Rao, Carlos A. Vivas, Corry, Corry, Corry, Corry, Corry, Egidi, Fioretto, Fontes, Greussner, Gruessner, Igor Dvorchik, John J. Fung, Jordan, Kapur, Mark L. Jordan, Nghiem, Pinna, Pradip K. Chakrabarti, Rao, Robert J. Corry, Ron Shapiro, Scantlebury, Shapiro, Sollinger, Starzl, Starzl, Starzl, Sugitani, Thomas E. Starzl, Tyden, Tyden, Velma P. Scantlebury, Wakely, Zehr   +35 more
core   +2 more sources