Results 141 to 150 of about 157,199 (404)

A Steady‐State Head‐to‐Head Pharmacokinetic Comparison of All FK‐506 (Tacrolimus) Formulations (ASTCOFF): An Open‐Label, Prospective, Randomized, Two‐Arm, Three‐Period Crossover Study

American Journal of Transplantation, 2016
This two‐sequence, three‐period crossover study is the first pharmacokinetic (PK) study to compare all three innovator formulations of tacrolimus (twice‐daily immediate‐release tacrolimus capsules [IR‐Tac]; once‐daily extended‐release tacrolimus capsules
S. Tremblay, V. Nigro, J. Weinberg, E. Woodle, R. Alloway   +4 more
semanticscholar   +1 more source

Improving Production of Tacrolimus In Streptomyces Tacrolimicus (ATCC 55098) Through Development of Novel Mutant by Dual Mutagenesis

Brazilian Archives of Biology and Technology, 2017
Tacrolimus is a polyketide macrolide produced by Streptomyces species which is widely used as anti-fibrotic agent and potent immunosuppressant. In this article dual mutagenesis approach using mutagens (NTG+EMS+UV) was used to develop a mutant strain of ...
Bhanu P Singh, Punit Kumar, Shafiul Haque, Arshad Jawed, Kashyap Kumar Dubey   +4 more
doaj   +1 more source

A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype‐Based With Body‐Weight‐Based Tacrolimus Dosing After Living Donor Kidney Transplantation

American Journal of Transplantation, 2016
Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with nonexpressers.
N. Shuker, R. Bouamar, R. H. Schaik, M. C. Clahsen‐van Groningen, J. Damman, C. Baan, J. Wetering, A. Rowshani, W. Weimar, T. Gelder, D. Hesselink   +10 more
semanticscholar   +1 more source

Safety of a trial of labor after cesarean in kidney and liver transplant recipients: A multicenter cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the trends, safety, and feasibility of a trial of labor after cesarean (TOLAC) among kidney and liver transplant recipients. Methods This was a retrospective cohort study using the Transplant Pregnancy Registry International.
Anjali Walia, Ophelia Yin, Lisa A. Coscia, Serban Constantinescu, Monika Sarkar, Michael J. Moritz, Yalda Afshar, Roxanna A. Irani   +7 more
wiley   +1 more source

Impact of genetic polymorphisms on tacrolimus concentrations and intra-individual variability in recipients of heart transplants during the early post-heart transplantation period [PDF]

arXiv
This study aimed to investigate the effects of genetic polymorphisms on tacrolimus blood levels and intra-individual variability in recipients of heart transplants during the early post-transplantation period. Demographic information, concomitant medications, daily tacrolimus dose, trough concentration, and physiological and biochemical information of ...
arxiv  

Clinical Pharmacokinetics and Drug‐Drug Interaction Potential for Coadministered SCY‐078, an Oral Fungicidal Glucan Synthase Inhibitor, and Tacrolimus

Clinical pharmacology in drug development, 2018
SCY‐078 is an orally bioavailable triterpenoid glucan synthase inhibitor in clinical development as an intravenous and oral treatment of fungal infections caused by Candida and Aspergillus species. This was a sequential, single‐center, open‐label phase 1
S. Wring, G. Murphy, G. Atiee, Christy Corr, M. Hyman, M. Willett, D. Angulo   +6 more
semanticscholar   +1 more source

Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis [PDF]

, 1992
B V Jegasothy
openalex   +1 more source

FIGO guideline on liver disease and pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The number of women entering pregnancy with chronic liver disease is rising. Gestational liver disorders affect 3% of the pregnant population. Both can be associated with significant maternal and fetal morbidity and mortality. European guidance has recently been published to inform management.
Melanie Nana, Virna Medina, Cynthia Maxwell, Ciara McCormick, Gloria Taliani, Ulrich Beuers, Deborah Money, Bo Jacobsson, Anil Kapur, Titus Beyuo, Francisco Ruiloba, Graeme Smith, Lina Bergman, Sharleen O'Reilly, Patrick O'Brien, Mark Hanson, Mary Rosser, Claudio Sosa, Sumaiya Adam, Valerie Guinto, Liona Poon, Fionnuala McAuliffe, Catherine Williamson, on behalf of the FIGO Committee on Impact of Pregnancy on Long‐term Health, FIGO Committee on Infections during Pregnancy and the FIGO Division of Maternal and Newborn Health   +24 more
wiley   +1 more source

Drug-drug interaction between diltiazem and tacrolimus in relation to CYP3A5 genotype status in Chinese pediatric patients with nephrotic range proteinuria: a retrospective study

Frontiers in Pharmacology
BackgroundTacrolimus is widely used to treat pediatric nephrotic range proteinuria (NRP). Diltiazem, a CYP3A4/5 inhibitor, is often administered with tacrolimus, affecting its pharmacokinetic profile. The impact of this combination on tacrolimus exposure,
Qiaoling Yang, Qiaoling Yang, Yan Wang, Yan Wang, Xuebin Wang, Ping Wang, Boyu Tan, Yijun Li, Huajun Sun, Wenyan Huang, Hongxia Liu   +10 more
doaj   +1 more source

A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

Haematologica, 2012
Background There is evidence suggesting that sirolimus, in combination with tacrolimus, is active in the prevention of graft-versus-host disease. Sirolimus-based immune suppression may suppress alloreactive T cells, while sparing the survival and ...
Joseph Pidala, Jongphil Kim, Heather Jim, Mohamed A. Kharfan-Dabaja, Taiga Nishihori, Hugo F. Fernandez, Marcie Tomblyn, Lia Perez, Janelle Perkins, Mian Xu, William E. Janssen, Anandaraman Veerapathran, Brian C. Betts, Frederick L. Locke, Ernesto Ayala, Teresa Field, Leonel Ochoa, Melissa Alsina, Claudio Anasetti   +18 more
doaj   +1 more source