Results 171 to 180 of about 73,761 (306)

Therapeutic drug monitoring of tacrolimus after kidney transplantation: trough concentration or area under curve‐based monitoring?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Measurement of pre‐dose tacrolimus concentrations, also referred to as trough concentrations or C0 (in this paper the term C0 will be used), is the most frequently used parameter for therapeutic drug monitoring in patients after solid organ transplantation. C0 is relatively easy to obtain, and can be combined with other lab tests.
Teun van Gelder, Armin Gelinck, Soufian Meziyerh, Aiko P. J. de Vries, Dirk Jan A. R. Moes   +4 more
wiley   +1 more source

Revisiting the nature and pharmacodynamics of tacrolimus metabolites

Pharmacological Research
The toxicity of tacrolimus metabolites and their potential pharmacodynamic (PD) interactions with tacrolimus might respectively explain the surprising combination of higher toxicity and lower efficacy of tacrolimus despite normal blood concentrations ...
Rudy Mevizou, Hassan Aouad, François-Ludovic Sauvage, Hélène Arnion, Emilie Pinault, Jean-Sébastien Bernard, Gildas Bertho, Nicolas Giraud, Rodolphe Alves de Sousa, Adolfo Lopez-Noriega, Florent Di Meo, Mélanie Campana, Pierre Marquet   +12 more
doaj  

Induction Therapy With Oral Tacrolimus Provides Long-Term Benefit in Thiopurine-Naïve Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels. [PDF]

JGH Open
Igawa S, Inokuchi T, Hiraoka S, Toyosawa J, Aoyama Y, Yamasaki Y, Kinugasa H, Takahara M, Okada H, Otsuka M.   +9 more
europepmc   +1 more source

Removing the physician from the equation: Patient‐controlled, home‐based therapeutic drug self‐monitoring of tacrolimus

British Journal of Clinical Pharmacology, EarlyView.
The dosing of tacrolimus, which forms the backbone of immunosuppressive therapy after kidney transplantation, is complex. This is due to its variable pharmacokinetics (both between and within individual patients), narrow therapeutic index, and the severe consequences of over‐ and underexposure, which may cause toxicity and rejection, respectively ...
Marinus Hazenbroek, Liset H. M. Pengel, Sebastiaan D. T. Sassen, Emma K. Massey, Marlies E. J. Reinders, Brenda C. M. de Winter, Dennis A. Hesselink   +6 more
wiley   +1 more source

Impact of <i>CYP3A4</i> and <i>ABCB1</i> genetic variants on tacrolimus dosing in Greek kidney transplant recipients. [PDF]

Front Pharmacol
Tsironi A, Lazaros K, Mendrinou E, Papasotiriou M, Siamoglou S, Kydonopoulou K, John A, Gerou A, Gerou S, Ali BR, Vrahatis AG, Patrinos GP.   +11 more
europepmc   +1 more source

Tacrolimus--finally! [PDF]

Gut, 2006
K R, Herrlinger, K, Fellermann, E F, Stange   +2 more
openaire   +2 more sources

Challenges for the improvement of valganciclovir prophylaxis in solid organ transplantation and the possible role of therapeutic drug monitoring in adults

British Journal of Clinical Pharmacology, EarlyView.
Cytomegalovirus (CMV) infection frequently occurs after solid organ transplantation and is associated with an increased morbidity and mortality. Fortunately, the development of valganciclovir prophylaxis has lowered the incidence of CMV infection and its complications in immunosuppressed solid organ transplant recipients.
Lukas K. van Vugt, Dennis A. Hesselink, Brenda C. M. de Winter   +2 more
wiley   +1 more source

A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions. [PDF]

Sci Rep
Zhao YC, Zhang YK, Gao W, Liu HY, Xiao CL, Hou JJ, Li JK, Zhang BK, Xiang DX, Sandaradura I, Yan M.   +10 more
europepmc   +1 more source

The potential for therapeutic drug monitoring of belatacept and other biologicals in solid organ transplantation

British Journal of Clinical Pharmacology, EarlyView.
Abstract In solid organ transplantation (SOT), biologicals such as recombinant therapeutic proteins, monoclonal antibodies, fusion proteins and conjugates are increasingly used for immunosuppression, desensitization, ABO (blood group) incompatibility, antibody‐mediated rejections and atypical haemolytic uremic syndrome.
Stein Bergan, Nils Tore Vethe
wiley   +1 more source

Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients. [PDF]

Front Pharmacol
Lindarte EF, De Jesus Vasquez G, Toro Rendón LG, Zuluaga Salazar AF, Buendia JA.   +4 more
europepmc   +1 more source