Results 261 to 270 of about 76,984 (297)
Some of the next articles are maybe not open access.
Journal of Cutaneous Medicine and Surgery, 2001
Background: Tacrolimus (FK 506), a metabolite of the fungus Streptomyces tsukubaensis, is an anti-T-cell drug. It acts by inhibiting the production of IL-2, IL-3, IL-4, TNFα, and GM-CSF. More potent and with slightly less secondary effects than cyclosporine, it has been the object of considerable interest, especially in conditions that could benefit ...
Jacqueline Tousignant +3 more
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Background: Tacrolimus (FK 506), a metabolite of the fungus Streptomyces tsukubaensis, is an anti-T-cell drug. It acts by inhibiting the production of IL-2, IL-3, IL-4, TNFα, and GM-CSF. More potent and with slightly less secondary effects than cyclosporine, it has been the object of considerable interest, especially in conditions that could benefit ...
Jacqueline Tousignant +3 more
openaire +2 more sources
The Journal of Heart and Lung Transplantation, 2007
Prior retrospective studies have suggested that tacrolimus monotherapy is an option associated with excellent outcomes and reduced toxicities.We conducted a prospective, randomized, 2-center study of tacrolimus combination therapy vs monotherapy. From April 16, 2004, to September 15, 2005, 58 adult heart transplant patients were studied.
L.H. Arroyo +10 more
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Prior retrospective studies have suggested that tacrolimus monotherapy is an option associated with excellent outcomes and reduced toxicities.We conducted a prospective, randomized, 2-center study of tacrolimus combination therapy vs monotherapy. From April 16, 2004, to September 15, 2005, 58 adult heart transplant patients were studied.
L.H. Arroyo +10 more
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Chronopharmacokinetics of Ciclosporin and Tacrolimus
Clinical Pharmacokinetics, 2006The correct use of immunosuppressive drugs has a considerable influence on the prognosis of patients with organ transplants. The appropriate utilisation of the drugs involves the administration of an adequate dosage to reach the blood concentrations that will suppress the alloimmune response, while avoiding secondary toxicities.
BARALDO, Massimo, FURLANUT, Mario
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Tacrolimus metabolite cross-reactivity in different tacrolimus assays
Clinical Biochemistry, 1998Tacrolimus (FK506) is an immunosuppressive drug with great clinical promise. There is a controversy regarding the role of tacrolimus metabolites in immunosuppression and toxicity, and immunoassays and immunophilin binding assays have not been adequately tested for metabolite cross-reactivity.
Diane L Davis +6 more
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Seminars in Veterinary Medicine and Surgery: Small Animal, 1997
Cyclosporine and tacrolimus are potent immunosuppressant agents that have been used extensively in humans, primarily for prevention of transplant rejection but also for the treatment of autoimmune disorders. Both agents have similar mechanisms of action and pharmacokinetic profiles. However, the expected toxicity of the agents is dissimilar.
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Cyclosporine and tacrolimus are potent immunosuppressant agents that have been used extensively in humans, primarily for prevention of transplant rejection but also for the treatment of autoimmune disorders. Both agents have similar mechanisms of action and pharmacokinetic profiles. However, the expected toxicity of the agents is dissimilar.
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Annals of Allergy, Asthma & Immunology, 1999
Objective The focus of this review is to summarize the mechanism of action, animal and clinical studies, and adverse effects of tacrolimus (FK 506) in treatment after solid organ transplantation and in treatment of autoimmune diseases. Data Sources A detailed search of the literature was done.
Erik Letko +4 more
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Objective The focus of this review is to summarize the mechanism of action, animal and clinical studies, and adverse effects of tacrolimus (FK 506) in treatment after solid organ transplantation and in treatment of autoimmune diseases. Data Sources A detailed search of the literature was done.
Erik Letko +4 more
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Drug Interactions with Tacrolimus
Drug Safety, 2002Tacrolimus is a drug for which therapeutic drug monitoring is recommended. The existence of a wide variety of potential drug interactions further supports the current strategy of measuring whole blood tacrolimus concentrations in transplanted patients.
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Tacrolimus in liver transplantation
Expert Opinion on Investigational Drugs, 1999Tacrolimus has been in clinical use for ten years. It was launched in a hail of publicity following the successful treatment of cases with apparently irreversible rejection using conventional immunosuppressive therapies. Since that time, the overall experience with the drug has increased considerably. The purpose of this article is to review tacrolimus
Mervyn H. Davies, Piyawat Komolmit
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Annals of Pharmacotherapy, 2006
Objective: To review the pharmacokinetics, efficacy, adverse effects, and clinical trials of modified-release tacrolimus (MR-4) concerning its equivalence to non-modified-release tacrolimus. Data Sources: A PubMed/MEDLINE search was conducted (1966–July 2005) using the following terms: MR-4, tacrolimus, FK506, Prograf, transplantation, calcineurin ...
Marie A. Chisholm, Matthew D Middleton
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Objective: To review the pharmacokinetics, efficacy, adverse effects, and clinical trials of modified-release tacrolimus (MR-4) concerning its equivalence to non-modified-release tacrolimus. Data Sources: A PubMed/MEDLINE search was conducted (1966–July 2005) using the following terms: MR-4, tacrolimus, FK506, Prograf, transplantation, calcineurin ...
Marie A. Chisholm, Matthew D Middleton
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Tacrolimus in Dermatologic Disorders
The Annals of Pharmacotherapy, 2001OBJECTIVE: To review the data surrounding the use of tacrolimus for skin disorders. DATA SOURCES: Articles were obtained through a MEDLINE search of English-language literature (1990–May 2000); references of the retrieved publications were further reviewed for relevant literature.
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