Results 81 to 90 of about 157,199 (404)

Lactobacillus fermentum Improves Tacrolimus‐Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

Molecular Nutrition & Food Research, 2018
SCOPE The aim is to analyze whether the probiotic Lactobacillus fermentum CECT5716 (LC40) can prevent endothelial dysfunction and hypertension induced by tacrolimus in mice.
M. Toral, M. Romero, A. Rodríguez‐Nogales, R. Jiménez, Iñaki Robles-Vera, F. Algieri, N. Chueca-Porcuna, M. Sánchez, Néstor de la Visitación, M. Olivares, Federico García, F. Pérez-Vizcaino, J. Gálvez, J. Duarte   +13 more
semanticscholar   +1 more source

Clinical Factors Associated With Pneumocystis Pneumonia Despite Its Primary Prophylaxis: When to Stop Prophylaxis?

Arthritis &Rheumatology, EarlyView.
Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim, Se Rim Choi, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Jun Won Park   +5 more
wiley   +1 more source

An Analysis of Early Renal Transplant Protocol Biopsies - the High Incidence of Subclinical Tubulitis [PDF]

, 2001
To investigate the possibility that we have been underestimating the true incidence of acute rejection, we began to perform protocol biopsies after kidney transplantation. This analysis looks at the one-week biopsies. Between March 1 and October 1, 1999,
Burdick, D'Ardenne, Hanas, Kjellstrand, Racusen, Randhawa, Rush, Rush, Rush, Saad, Seron, Shapiro, Shapiro, Shapiro, Shapiro, Solez, Starzl   +16 more
core   +1 more source

Plasma Versus Whole Blood Tacrolimus Concentrations and Health-Related Quality of Life in Kidney Transplant Recipients

Pharmaceutics
Background/Objectives: Tacrolimus dosing traditionally relies on therapeutic drug monitoring in whole blood, while assessment in plasma may better reflect its effect and reveal overdosing impacting health-related quality of life (HRQoL). Methods: In this
Svea Nolte, J. Casper Swarte, Tim J. Knobbe, Ilja M. Nolte, Tanja R. Zijp, Harmen R. Moes, Marco van Londen, Niels L. Riemersma, Johannes R. Björk, Rinse K. Weersma, Gea Drost, Stefan P. Berger, Daan J. Touw, Stephan J. L. Bakker   +13 more
doaj   +1 more source

A cohort study on the risk of lymphoma and skin cancer in users of topical tacrolimus, pimecrolimus, and corticosteroids (Joint European Longitudinal Lymphoma and Skin Cancer Evaluation – JOELLE study)

Clinical Epidemiology, 2018
Background There is a concern that topical tacrolimus and pimecrolimus, indicated for second-line treatment of atopic dermatitis, may increase the risk of lymphoma and skin cancer, particularly in children.
J. Castellsagué, J. Kuiper, A. Pottegård, I. Anveden Berglind, D. Dedman, L. Gutiérrez, B. Calingaert, M. V. van Herk-Sukel, J. Hallas, A. Sundström, A. Gallagher, J. Kaye, C. Pardo, K. Rothman, S. Perez-Gutthann   +14 more
semanticscholar   +1 more source

Tacrolimus‐Related Neurotoxicity of the Pons in Children: Review of the Literature and a Case Report

Annals of the Child Neurology Society
Introduction Tacrolimus is a potent immunosuppressive agent effective in preventing solid organ transplant rejection. It is widely used following allogeneic liver, kidney, heart, and bone marrow transplantation.
Amy Hill, Mohamed Bilal Haradwala, Jean‐Baptiste Le Pichon   +2 more
doaj   +1 more source

Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients.

American Journal of Kidney Diseases, 2018
BACKGROUND Differences in tacrolimus dosing across ancestries is partly attributable to polymorphisms in CYP3A5 genes that encode tacrolimus-metabolizing cytochrome P450 3A5 enzymes.
J. Trofe‐Clark, D. Brennan, P. West-Thielke, M. Milone, M. Lim, R. Neubauer, V. Nigro, R. Bloom   +7 more
semanticscholar   +1 more source

Effect of long‐term voclosporin treatment on renal histology in patients with active lupus nephritis with repeat renal biopsies

Arthritis &Rheumatology, Accepted Article.
Objective This study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials. Methods Patients were randomized to voclosporin or placebo treatment for up to three years; all patients received mycophenolate mofetil and low‐dose ...
Brad H. Rovin, Clarissa Cassol, Samir V. Parikh, Amit Saxena, Neil Solomons, Vanessa Birardi, Ernie Yap, Clint W. Abner, David R.W. Jayne, Robert B. Huizinga   +9 more
wiley   +1 more source

Alemtuzumab preconditioning with tacrolimus monotherapy - The impact of serial monitoring for donor-specific antibody [PDF]

, 2008
BACKGROUND. Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning. METHODS.
Adriana Zeevi, Alin L. Girnita, Amadeo Marcos, Amit Basu, Calne, Deanna M. Blisard, Edward A. Gray, Girnita, Henkie P. Tan, Kirk, Knechtle, Kowalski, Liise K. Kayler, Mao, Meier-Kriesche, Mizutani, Montgomery, Ngoc L. Thai, Parmjeet S. Randhawa, Pascual, Pei, Ron Shapiro, Shapiro, Shapiro, Shapiro, Starzl, Stuart, Tan, Thomas E. Starzl, Waldmann   +29 more
core   +1 more source

Immunosuppressive effect of the gut microbiome altered by high‐dose tacrolimus in mice

American Journal of Transplantation, 2018
The alterations induced in gut microbiota by tacrolimus may affect immune function and organ transplantation. Mice were treated with high‐dose tacrolimus for 14 days. The fecal microbiota were analyzed by pyrosequencing the 16S rRNA genes, and the effect
Zijian Zhang, L. Liu, Hao Tang, W. Jiao, S. Zeng, Yue Xu, Q. Zhang, Zhaoli Sun, Amiya K. Mukherjee, X. Zhang, Xiaopeng Hu   +10 more
semanticscholar   +1 more source