Results 101 to 110 of about 34,240 (280)

Integration bile acid metabolomics and gut microbiome to study the anti-liver fibrosis effects of total alkaloids of Corydalis saxicola Bunting

Chinese Medicine
Background Bile acids and gut microbiota participate in the pathogenesis of liver fibrosis (LF). The total alkaloids of Corydalis saxicola Bunting (TACS) is a traditional Chinese medicine extract that has been used to treat LF, but the underlying ...
Qianyi Wang, MeiLing Zhang, Mingwei Meng, Zhuo Luo, Ziping Pan, Lijun Deng, Jinghua Qin, Bingjian Guo, Dan Zhu, Yanmin Zhang, Hongwei Guo, Yonghong Liang, Zhiheng Su   +12 more
doaj   +1 more source

Active Resource Request and Release by Backup Localization System under TACS On-board Controller Failures

Chengshi guidao jiaotong yanjiu
[Objective] When the onboard controller in TACS (train autonomous circumnavigation system) fails, the trackside resource request and release cannot be carried out successfully.
FEI Bojun
doaj   +1 more source

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

Developmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser, Timothy T. Nguyen, Kayla M. Henry, Mariela Rosales, Eric Van Otterloo, Chad E. Grueter   +5 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

The modulation of steady-state responses by transcranial alternating current stimulation: a scoping review

Frontiers in Systems Neuroscience
Transcranial alternating current stimulation (tACS) is a non-invasive technique that modulates brain oscillatory activity in a frequency-specific manner, offering potential for improving sensory and cognitive functions.
Aurimas Mockevičius, Aurimas Mockevičius, Jovana Bjekić, Inga Griškova-Bulanova, Inga Griškova-Bulanova   +4 more
doaj   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

DELirium treatment with Transcranial Electrical Stimulation (DELTES): study protocol for a multicentre, randomised, double-blind, sham-controlled trial

BMJ Open
Introduction Delirium, a clinical manifestation of acute encephalopathy, is associated with extended hospitalisation, long-term cognitive dysfunction, increased mortality and high healthcare costs.
Arjen J C Slooter, Marielle H Emmelot-Vonk, Julia van der A, Yorben Lodema, Thomas H Ottens, Dennis J L G Schutter, Willem de Haan, Edwin van Dellen, Indira Tendolkar   +8 more
doaj   +1 more source

Project Technical Report MSC/TRW Task KM-205 - SLP OWS Control System Digital Simulation Requirements [PDF]

Digital simulation of AAP orbital workshop pointing control system and thrust attitude control ...
Mc Gee, C. F., Smith, T. J.
core   +1 more source

Integrated Flue‐Gas Heat Recovery for Optimized Steam and Power Generation Using Organic Rankine Cycle (ORC): A Technical and Economic Assessment

Energy Science &Engineering, EarlyView.
Integration of a steam cycle with an existing gas turbine increased efficiency from 32% to 51%, reducing fuel consumption by 21.4% and CO2 emissions by 18.6%. The modification generated USD 13.9 million annual savings and lowered the Levelized Cost of Energy to 38.7 USD/MWh, with a 3‐year payback.
Vahid Pirouzfar, Anashe Aghajani, Chia‐Hung Su   +2 more
wiley   +1 more source