Results 141 to 150 of about 2,066 (198)
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 2, June 2026.Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes
Protein Science, Volume 35, Issue 6, June 2026.Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin +2 more
wiley +1 more source
Pitfalls and missing links in current understanding of 4D genomes
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley +1 more source
Small, Volume 22, Issue 33, 12 June 2026.Single‐walled carbon nanotubes (SWCNTs) are versatile optical nanosensors that can be imaged at the single‐sensor level to map biological processes. To translate such imaging into calibrated measurements, sensor recovery under repeated analyte exposures must be analyzed.
Geffen Rosenberg, Gili Bisker
wiley +1 more source
Excess Rainfall Threatens Monsoon Crop Yield Stability Under Climate Change
Earth's Future, Volume 14, Issue 6, June 2026.Abstract Growing season rainfall variations strongly govern crop productivity, especially in monsoonal agricultural systems such as those in the Indian subcontinent. The optimum rainfall threshold (ORT), defined as the rainfall amount resulting in maximum yields, is a critical yet underexamined factor in achieving stable and high agricultural ...
Arabinda Maiti +11 more
wiley +1 more source
Predictive Models for Postfire Debris Flow Initiation in the Southwest USA
Journal of Geophysical Research: Earth Surface, Volume 131, Issue 6, June 2026.Abstract Postfire debris flows pose a threat to life and infrastructure and significantly contribute to sediment supply in upland channels, thereby impacting water quality, stream habitats, and landscape evolution. Models designed to assess postfire debris‐flow likelihood at the watershed scale in response to design or forecast rainstorms are ...
Ana Isabel Fernandez Sirgo +3 more
wiley +1 more source
Cancer Science, Volume 117, Issue 6, Page 1736-1747, June 2026.This study investigates whether several AF2‐derived scores can predict functional scores and pathogenicity labels, and suggests that the root mean square deviation between the wild‐type and variant structures predicted by AlphaFold2 (ROWVA) may be the most effective predictor. This approach may also be applicable to other multimeric proteins.
Taiki Furutani +7 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, Volume 66, Issue 6, Page 1330-1341, June 2026.Plain Language Summary Recent studies have found an association between migraine and several chronic inflammatory diseases, such as multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis, suggesting that these conditions might share common immune and vascular pathways.
María Clara García‐Castillo +37 more
wiley +1 more source
The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley +1 more source