Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3. [PDF]
Akilli N +8 more
europepmc +1 more source
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
Targeted axillary dissection using Magseed magnetic bead in female patients with breast cancer. [PDF]
Toman D +9 more
europepmc +1 more source
Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad +4 more
wiley +1 more source
Internal-locking intramedullary nails (talons, claws, wings, wedge-locks, endopins): a mechanics-guided scoping review of designs, failure signatures, and technique imperatives. [PDF]
Yapici F.
europepmc +1 more source
Tad Seestedt is photographed during an oral history interview at Ransom Wine and Spirits in Sheridan, Oregon on March 30, 2018. Seestedt was interviewed by Linfield College archivist Rich Schmidt. Tad Seestedt is the owner of Ransom Wine Co. & Distillery.
Linfield College Archives
core
NMR Investigation of Water in Mesoporous Silica Materials With Different Surfaces
Narrow pores of mesoporous silica are filled with water in an axial mode, independent of the surface hydrophobicity. The influence of the hydrophilicity of mesoporous silica on wetting with water was investigated by comparing a standard hydrophilic MCM‐41 and a partially hydrophobicized material obtained by trimethylsilylation of MCM‐41.
Yanjing Zhao +3 more
wiley +1 more source
Antonio Lázaro-Reboll, Spanish horror film, Edinburgh, University Press Edinburg, 2012.
Rubén Sánchez
doaj +1 more source
Foundation model reveals the shared organization of transcription and topologically associating domains. [PDF]
Liang H, Berger B, Singh R.
europepmc +1 more source

