Results 151 to 160 of about 2,066 (198)
ABSTRACT Chromatin interactions establish spatial proximity between distant regulatory elements and their target genes, significantly influencing gene expression, and phenotypic traits. In this study, we present a plant chromatin interaction prediction model called PlantCTCIP based on Convolutional Neural Networks and Transformer.
Zhenye Wang +14 more
wiley +1 more source
(Co‐)Reference All the Way Down: A Unified Theory of (Pro) Nominals in Ordinary English
ABSTRACT This essay joins two themes, both arising from Kripke's inspiring ideas in the theory of reference. The first theme concerns reference in general. The second examines the notion of co‐reference and the role it plays in a unified theory of pronouns for natural language.
Jessica Pepp, Joseph Almog
wiley +1 more source
Redox Disruption Induced by Saquayamycin B1 Promotes Cytotoxicity in Resistant Melanoma Cells
Saquayamycin B1 (SQ‐B1), an antibiotic isolated from Streptomyces sp. I072, triggers cell death in different melanoma cell lines, including chemoresistant SK‐MEL‐5. SQ‐B1 elevates O2•‐ and NO• on both sides of the membrane and blocks glutathione transferase (GSTP‐1) and glutathione reductase (GSR), destabilizing the GSH/GSSG antioxidant system.
Geovana Guedes Silvestre +13 more
wiley +1 more source
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All-digital MEMS gyro-sensor using TAD-digital-synchronous-detection (TAD-DSD) By TAD-ADPLL
2015 IEEE SENSORS, 2015As sensor digitization for IoT-applications, this paper presents an all-digital MEMS gyro-sensor circuit method, using TAD (Time-A/D converter)-based digital synchronous detection (TAD-DSD) by applying entirely all-digital time-domain processing, which uses no conventional methods such as analogmixers, -filters and -ADCs.
Takamoto Watanabe
exaly +2 more sources
Nature Genetics, 2020
Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene
Irene Farabella, Marc A. Marti-Renom
openaire +2 more sources
Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene
Irene Farabella, Marc A. Marti-Renom
openaire +2 more sources
Molecular Cell, 2022
In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.
Davide, Michieletto, Wendy A, Bickmore
openaire +2 more sources
In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.
Davide, Michieletto, Wendy A, Bickmore
openaire +2 more sources
NIMH's TADS: More than just a tad of progress?
Cognitive and Behavioral Practice, 2005The Treatment for Adolescents With Depression Study (TADS) derives substantial public health significance from its head-to-head comparisons of carefully administered medication versus a carefully crafted cognitive-behavioral therapy in youth with major depression, the first major clinical trial of its kind.
openaire +1 more source
TADs: an evolutionary road to success
Dental Update, 2014This is a literature search about the clinical use of temporary anchorage devices (TADs) as a means of providing effective orthodontic anchorage. It takes the reader through a journey from the initial description of the technique to the enormous popularity TADs are currently experiencing in clinical practice.
Audrey, Pace, Jonathan, Sandler
openaire +2 more sources
Journal of Molecular Biology, 2020
Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs).
openaire +2 more sources
Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs).
openaire +2 more sources

