Results 131 to 140 of about 2,066 (198)

Genetic and Clinical Features in TP53‐Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next‐Generation Sequencing Data

open access: yesCancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background The recent fifth edition of World Health Organization and International Consensus Classification in 2022 recognized TP53‐mutated myelodysplastic neoplasms (MDS) as a distinct entity requiring multi‐hit classification. Literatures indicate that TP53 variant alle frequency (VAF) correlates with clinical outcomes.
Yanming Cheng   +7 more
wiley   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao   +5 more
wiley   +1 more source

The Effects of Inspiratory Muscle Training on Diaphragm Thickness, Respiratory Muscle Strength, Balance, and Core Stability in Professional Dancers: A Randomized Controlled Trial

open access: yesEuropean Journal of Sport Science, Volume 26, Issue 6, June 2026.
ABSTRACT This study aimed to investigate the effects of progressive resistance IMT on diaphragm muscle thickness, inspiratory muscle strength, balance, and isometric endurance of the hip‐back extensor muscles in professional dancers. Thirty‐six professional dancers (15 male, 21 female) aged 16–47 years were randomly assigned to either a training group (
Hakan Aksu   +3 more
wiley   +1 more source

Cytogenetic and Molecular Analysis of a “Double‐Hit” RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia

open access: yesGenes, Chromosomes and Cancer, Volume 65, Issue 6, June 2026.
ABSTRACT Introduction Alterations involving RUNX1 are recurrent in hematologic malignancies and contribute to disease pathogenesis via dysregulation of transcriptional factors essential for hematopoiesis. Here, we report an acquired alteration in both alleles of RUNX1; one is a truncating mutation and the second is a novel RUNX1::ARID1B identified in ...
Rolando García   +8 more
wiley   +1 more source

Genetic Variants of BMI1 (rs1042059 and rs11591377) and Their Potential Role in Leukemia Susceptibility: A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Leukemia is a heterogeneous group of hematologic malignancies influenced by both genetic and environmental factors. The B‐cell‐specific Moloney murine leukemia virus integration site 1 (BMI1) gene, a key regulator of hematopoietic stem cell self‐renewal and oncogenesis, has been implicated in leukemia pathogenesis.
Mojtaba Aghaei   +2 more
wiley   +1 more source

Emerging Perovskite Solar Cells for Building‐Integrated Photovoltaic Applications

open access: yesInformation &Functional Materials, Volume 3, Issue 2, Page 156-177, June 2026.
In this review, we discuss technological approaches of perovskite solar cells that are highly compatible with the requirements of building‐integrated photovoltaic applications, including semi‐transparent, colorful, and flexible perovskite solar cells.
Yongke Liang   +4 more
wiley   +1 more source

Biological Drivers of IMiD‐Induced Peripheral Neuropathy in Multiple Myeloma

open access: yeseJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT The introduction of immunomodulatory drugs (IMiDs), such as thalidomide, lenalidomide and pomalidomide, have led to significant improvements in multiple myeloma (MM) treatment. Many patients now live 10 years or longer with their disease, making treatment‐related side effects increasingly important.
Sina A. Beer   +2 more
wiley   +1 more source

Direct comparison of reconsolidation of traumatic memories and prolonged exposure therapy: A randomized controlled trial

open access: yesJournal of Traumatic Stress, Volume 39, Issue 3, Page 529-540, June 2026.
Abstract New therapies are needed for posttraumatic stress disorder (PTSD), particularly in military service members (SMs). Reconsolidation of traumatic memories (RTM) is a novel treatment with promising results in small clinical trials. We randomized 94 active duty or retired SMs (Mage = 45.80, 31.0% women) with PTSD to receive up to ten 90‐min ...
Michael J. Roy   +10 more
wiley   +1 more source

Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang   +7 more
wiley   +1 more source

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