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TADs: Dynamic structures to create stable regulatory functions
Current Opinion in Structural Biology, 2023 International audienceMammalian chromosomes are organized at different length scales within the cell nucleus. Topologically Associating Domains (TADs) are structural units of 3D genome organization with functions in gene regulation, DNA replication ...
Daan Noordermeer
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Nature Genetics, 2020
Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene
Irene Farabella, Marc A. Marti-Renom
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Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene
Irene Farabella, Marc A. Marti-Renom
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Regulation of single-cell genome organization into TADs and chromatin nanodomains [PDF]
Nature Genetics, 2020 Super-resolution microscopy identifies sub-topologically associating domain (TAD) nanodomains and intercellular heterogeneity in TAD conformation and insulation.
Jerkovic Jerkovic +2 more
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Molecular Cell, 2022
In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.
Davide, Michieletto, Wendy A, Bickmore
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In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.
Davide, Michieletto, Wendy A, Bickmore
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NIMH's TADS: More than just a tad of progress?
Cognitive and Behavioral Practice, 2005The Treatment for Adolescents With Depression Study (TADS) derives substantial public health significance from its head-to-head comparisons of carefully administered medication versus a carefully crafted cognitive-behavioral therapy in youth with major depression, the first major clinical trial of its kind.
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2023
ABSTRACT Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown.
Mariam, Okhovat +24 more
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ABSTRACT Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown.
Mariam, Okhovat +24 more
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All-digital MEMS gyro-sensor using TAD-digital-synchronous-detection (TAD-DSD) By TAD-ADPLL
2015 IEEE SENSORS, 2015As sensor digitization for IoT-applications, this paper presents an all-digital MEMS gyro-sensor circuit method, using TAD (Time-A/D converter)-based digital synchronous detection (TAD-DSD) by applying entirely all-digital time-domain processing, which uses no conventional methods such as analogmixers, -filters and -ADCs.
Takamoto Watanabe, Shigenori Yamauchi
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Journal of Molecular Biology, 2020
Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs).
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Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs).
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Journal of the Division for Early Childhood, 1983
This article discusses background and introductory material about TADS and its technical assistance (TA) contract with the U.S. Special Education Programs (SEP) and its Handicapped Children's Early Education Program (HCEEP). An overview to TA is provided along with a definition, description of related literature, and principles.
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This article discusses background and introductory material about TADS and its technical assistance (TA) contract with the U.S. Special Education Programs (SEP) and its Handicapped Children's Early Education Program (HCEEP). An overview to TA is provided along with a definition, description of related literature, and principles.
exaly +2 more sources