Results 1 to 10 of about 21,822,555 (337)
Current Opinion in Structural Biology, 2022 Eukaryotic DNA is packaged into nucleosomes, which further condenses into chromosomes. The telomeres, which form the protective end-capping of chromosomes, play a pivotal role in ageing and cancer. Recently, significant advances have been made in understanding the nucleosomal and telomeric chromatin structure at the molecular level. In addition, recent
Aghil Soman +2 more
openaire +4 more sources
The Force is Strong with This Epigenome: Chromatin Structure and Mechanobiology. [PDF]
J Mol Biol, 2023 All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms develop diverse mechanosensing and mechanotransduction pathways, leading to fast and sustained mechanoresponses.
Hsia CR, Melters DP, Dalal Y.
europepmc +2 more sources
Emerging roles of linker histones in regulating chromatin structure and function
Nature Reviews Molecular Cell Biology, 2017 Together with core histones, which make up the nucleosome, the linker histone (H1) is one of the five main histone protein families present in chromatin in eukaryotic cells.
Arthur Skoultchi +2 more
exaly +2 more sources
Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping
Nature, 2016 Chromatin structure at the length scale encompassing local nucleosome–nucleosome interactions is thought to play a crucial role in regulating transcription and access to DNA.
Aaron F Straight +2 more
exaly +2 more sources
Chromatin-Associated RNAs Regulate Gene Expression and Chromatin Structure [PDF]
Non-Coding RNAInside the eukaryotic nucleus, various RNAs are associated with chromatin. These include protein-coding pre-mRNA and different types of non-coding RNAs that are referred to as chromatin-associated RNAs (caRNAs). Recent studies have revealed the important
Bingning Xie, Ann Dean
doaj +2 more sources
BMC Molecular and Cell Biology, 2022 In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains, and larger chromatin compartments ...
Meng Wang +3 more
doaj +3 more sources
Cell, 2017 Summary Higher eukaryotic chromosomes are organized into topologically constrained functional domains; however, the molecular mechanisms required to sustain these complex interphase chromatin structures are unknown.
Ryu-Suke Nozawa +2 more
exaly +2 more sources
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
Nature Reviews Molecular Cell Biology, 2012 The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair.
David Tremethick
exaly +2 more sources
Trac-looping measures genome structure and chromatin accessibility
Nature Methods, 2018 Long-range chromatin interactions play critical roles in genome organization and regulation of transcription. We now report transposase-mediated analysis of chromatin looping (Trac-looping) for simultaneous detection of multiscale genome-wide chromatin ...
Gangqing Hu, Keji Zhao, Gang Ren
exaly +2 more sources
Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
doaj +1 more source