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Chromatin-Associated RNAs Regulate Gene Expression and Chromatin Structure [PDF]
Non-Coding RNAInside the eukaryotic nucleus, various RNAs are associated with chromatin. These include protein-coding pre-mRNA and different types of non-coding RNAs that are referred to as chromatin-associated RNAs (caRNAs). Recent studies have revealed the important
Bingning Xie, Ann Dean
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Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
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Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
Nature Communications, 2022 The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.
Rina Hirano +6 more
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Nucleosome Structures Built from Highly Divergent Histones: Parasites and Giant DNA Viruses
Epigenomes, 2022 In eukaryotes, genomic DNA is bound with histone proteins and packaged into chromatin. The nucleosome, a fundamental unit of chromatin, regulates the accessibility of DNA to enzymes involved in gene regulation.
Shoko Sato +2 more
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Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase
Life Science Alliance, 2021 Cryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue.
Cheng-Han Ho +5 more
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Communications Biology, 2021 Hirano et al. show that the H2A.B-H2B histone dimer incorporated within the nucleosome exchanges with the canonical H2A-H2B dimer without assistance from histone chaperones or nucleosome remodelers.
Rina Hirano +8 more
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The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function
mBio, 2023 Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALLINIs, namely,
Matthew R. Singer +14 more
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Multivalent interactions essential for lentiviral integrase function
Nature Communications, 2022 The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its function.
Allison Ballandras-Colas +19 more
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Interaction of the pioneer transcription factor GATA3 with nucleosomes
Nature Communications, 2020 GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor ...
Hiroki Tanaka +7 more
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Internal modifications in the CENP-A nucleosome modulate centromeric dynamics
Epigenetics & Chromatin, 2017 Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui +7 more
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