Results 41 to 50 of about 21,822,555 (337)

Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis

eLife, 2016
During embryogenesis, the initial chromatin state is established during a period of rapid proliferative activity. We have measured with 3-min time resolution how heritable patterns of chromatin structure are initially established and maintained during ...
Shelby A. Blythe, E. Wieschaus
semanticscholar   +1 more source

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]

, 2009
We present a quantitative Forster resonance energy transfer (FRET)-based assay using multiphoton fluorescence lifetime imaging microscopy (FLIM) to measure chromatin compaction at the scale of nucleosomal arrays in live cells. The assay uses a human cell
Angus I. Lamond, Norman, David G., James, John, Lleres, David, Lamond, Angus, I, John James, David Llères, Swift, Sam, David G. Norman, Norman, David, G, Lamond, Angus I.; id_orcid, Sam Swift   +11 more
core   +1 more source

Chromatin Structure in Telomere Dynamics [PDF]

Frontiers in Oncology, 2013
The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence.
GALATI, Alessandra, MICHELI, EMANUELA, CACCHIONE, Stefano   +2 more
openaire   +4 more sources

The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]

, 2012
The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P., Nathke, Inke S.; id_orcid, Ashwat Visvanathan, Daniel Klotz (158368), Inke S Näthke, Visvanathan, Ashwat, Gaganmeet S. Chadha (158365), Klotz Daniel, Swedlow, Jason R.; id_orcid, Visvanathan, A., Näthke, I.S., Chadha, Gaganmeet S., Gaganmeet S Chadha, Lamond Angus, Angus Lamond (158376), Dikovskaya Dina, Visvanathan Ashwat, Dikovskaya, Dina, Näthke Inke S., Lamond, A., Swedlow Jason R., Dina Dikovskaya (158354), Jason R. Swedlow (158382), Inke S. Näthke (158386), Newton Ian P., Lamond, Angus; id_orcid, Newton, I.P., Khoudoli, Guennadi, Khoudoli, G., Angus Lamond, Guennadi Khoudoli (158358), Dikovskaya, D., Daniel Klotz, Klotz, D., Jason R Swedlow, Khoudoli Guennadi, Chadha, G.S., Guennadi Khoudoli, Klotz, Daniel, Dina Dikovskaya, Ian P. Newton (158362), Chadha Gaganmeet S., Ashwat Visvanathan (158372), Swedlow, J.R., Ian P Newton   +44 more
core   +1 more source

NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]

, 2004
Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
core   +1 more source

THE STRUCTURE AND FUNCTION OF CHROMATIN AND CHROMOSOMES [PDF]

Biocomputing 2012, 2011
1. Background One of the striking features of the eukaryotic nucleus is that chromosomes adopt preferred conformations that vary across different tissues and developmental stages. Many lines of evidence suggest the functional significance of genome architecture, including the existence of chromosomes territories [1], the correlation between radial ...
William Stafford Noble, C. Anthony Blau, Job Dekker, Zhi-jun Duan, Yi Mao   +4 more
openaire   +3 more sources

The language of chromatin modification in human cancers

Nature Reviews. Cancer, 2021
The genetic information of human cells is stored in the context of chromatin, which is subjected to DNA methylation and various histone modifications.
Shuai Zhao, C. Allis, G. Wang
semanticscholar   +1 more source

Evolutionary dynamics of chromatin structure and duplicate gene expression in diploid and allopolyploid cotton [PDF]

, 2023
Polyploidy is a prominent mechanism of plant speciation and adaptation, yet the mechanistic understandings of duplicated gene regulation remain elusive. Chromatin structure dynamics are suggested to govern gene regulatory control.
Sui, Xin, Bass, Hank, Ou, Shujun, Girimurugan, Senthil, Li, Dongming, Lung, Pei-Yau, Hu, Guanjing, Vera, Daniel, Gallagher, Joseph, Conover, Justin, Grover, Corrinne, Xiong, Xianpeng, Zhu, De, Zhang, Jinfeng, Wendel, Jonathan, Miller, Emma, Udall, Joshua   +16 more
core  

Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]

, 2013
Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
core   +1 more source

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

Nature Communications, 2019
Kinetochore function depends on H4K20 monomethylation in centromeric nucleosomes but the underlying mechanism is unclear. Here, the authors provide evidence that the centromere-specific nucleosome subunit CENP-A facilitates H4K20 methylation by enabling ...
Yasuhiro Arimura, Hiroaki Tachiwana, Hiroki Takagi, Tetsuya Hori, Hiroshi Kimura, Tatsuo Fukagawa, Hitoshi Kurumizaka   +6 more
doaj   +1 more source