Results 51 to 60 of about 21,822,555 (337)

Old cells, new tricks: chromatin structure in senescence

Mammalian Genome, 2016
Cellular senescence is a stable form of cell cycle arrest with roles in many pathophysiological processes including development, tissue repair, cancer, and aging.
Aled J. Parry, Masashi Narita
semanticscholar   +1 more source

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26

Nature Communications
Rad26, a yeast homologue of mammalian Cockayne syndrome protein B (CSB), plays an essential role in transcription-coupled nucleotide excision repair (TC-NER).
Yutaro Fukushima, Chiaki Kinoshita, Lumi Negishi, Tomoya Kujirai, Yuki Kobayashi, Mitsuo Ogasawara, Haruhiko Ehara, Shun-ichi Sekine, Wataru Kagawa, Hitoshi Kurumizaka, Yoshimasa Takizawa   +10 more
doaj   +1 more source

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Nature Communications, 2019
Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into ...
Marcus D. Wilson, Ludovic Renault, Daniel P. Maskell, Mohamed Ghoneim, Valerie E. Pye, Andrea Nans, David S. Rueda, Peter Cherepanov, Alessandro Costa   +8 more
doaj   +1 more source

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Nature Communications, 2021
Understanding the pathology and immunological response to SARS CoV2 infection in specific patient groups is essential for informing the scientific and clinical handling of infections within these patient populations.
Aljawharah Alrubayyi, Ester Gea-Mallorquí, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa   +20 more
doaj   +1 more source

Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin Interactions

Nature, 2012
The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete.
Jesse R. Dixon, Siddarth Selvaraj, Feng Yue, Audrey Kim, Yan Li, Yin Shen, Ming Hu, Jun S. Liu, B. Ren   +8 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Kinetic control of eukaryotic chromatin structure by recursive topological restraints [PDF]

, 2008
Chromatin structure undergoes many changes during the cell cycle and in response to regulatory events. A basic unit of chromatin organization is the nucleosome core particle.
Dominika Borek, Zbyszek Otwinowski
core  

Identification and validation of transcription factors that regulate chromatin dynamics [PDF]

, 2012
Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core   +1 more source

Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome

Nature Communications
In mammalian global genomic nucleotide excision repair, UV-DDB plays a central role in recognizing DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers, within chromatin.
Syota Matsumoto, Yoshimasa Takizawa, Mitsuo Ogasawara, Kana Hashimoto, Lumi Negishi, Wenjie Xu, Haruna Tachibana, Junpei Yamamoto, Shigenori Iwai, Kaoru Sugasawa, Hitoshi Kurumizaka   +10 more
doaj   +1 more source

Cooperation between complexes that regulate chromatin structure and transcription.

Cell, 2002
Chromatin structure creates barriers for each step in eukaryotic transcription. Here we discuss how the activities of two major classes of chromatin-modifying complexes, ATP-dependent remodeling complexes and HAT or HDAC complexes, might be coordinated ...
G. Narlikar, Hua-Ying Fan, R. Kingston
semanticscholar   +1 more source