Results 31 to 40 of about 21,822,555 (337)
Coupling chromatin structure and dynamics by live super-resolution imaging
Science Advances, 2019 Deep-PALM, a time-resolved super-resolution microscopy, enables the simultaneous analysis of chromatin structure and dynamics. Chromatin conformation regulates gene expression and thus, constant remodeling of chromatin structure is essential to guarantee
R. Barth, K. Bystricky, H. Shaban
semanticscholar +1 more source
Job Opening for Nucleosome Mechanic: Flexibility Required
Cells, 2020 The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical ...
Mary Pitman +2 more
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Neutralization of the Positive Charges on Histone Tails by RNA Promotes an Open Chromatin Structure.
Cell Chemical Biology, 2019 RNA associates extensively with chromatin and can influence its structure; however, the potential role of the negative charges of RNA on chromatin structure remains unknown.
Rositsa Dueva +6 more
semanticscholar +1 more source
The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring
FEBS Open Bio, 2023 The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding.
Chiaki Kinoshita +5 more
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Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
doaj +1 more source
A model for chromatin structure [PDF]
Nucleic Acids Research, 1975 A model for chromatin structure is presented. (a) Each of four histone species, H2A (IIbl or f2a2), H2B (IIb2 or f2b), H3 (III or f3) and H4 (IV or f2al) can form a parallel dimer. (b) These dimers can form two tetramers, (H2A)2(H2b)2 and (H3)2(H4)2. (C) These two tetramers bind a segment of DNA and condense it into a "C" segments.
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Chromatin and nucleosome structure [PDF]
Nucleic Acids Research, 1976 Chromatin nucleosomes (mononucleosomes through pentanucleosomes) have been isolated by staphylococcal nuclease digestion of calf thymus nuclei. The peak value ellipticity is the same for all oligomers, 1900 deg cm2, mol-1 at 280-nm, 23 degrees C. The dh280/dT vs T show a progressive increase in Tm of the main thermal band (73.5 degrees C, monomer; 79 ...
R, Mandel, G D, Fasman
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NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
Nature Communications, 2018 Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique senescence phenotype in adjacent cells by specifically upregulating ...
Aled J. Parry +13 more
semanticscholar +1 more source
Unbiased high-throughput characterization of mussel transcriptomic responses to sublethal concentrations of the biotoxin okadaic acid [PDF]
PeerJ, 2015 Background. Harmful Algal Blooms (HABs) responsible for Diarrhetic Shellfish Poisoning (DSP) represent a major threat for human consumers of shellfish. The biotoxin Okadaic Acid (OA), a well-known phosphatase inhibitor and tumor promoter, is the primary ...
Victoria Suarez-Ulloa +7 more
doaj +2 more sources
, 2020 Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving coordinated waves of DNA methylation/demethylation, histone modification, and the replacement and removal that occurs before, during, and after meiosis ...
core +2 more sources