Results 31 to 40 of about 272,086 (309)

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Daniel P Ryan, Singh, Vijender, Owen-Hughes, Tom; id_orcid, Martin, David; id_orcid, David Martin, Ramasubramanian Sundaramoorthy, Vijender Singh, Sundaramoorthy, Ramasubramanian, Ryan, Daniel P., Tom Owen-Hughes   +9 more
core   +1 more source

Chromatin Structure in Telomere Dynamics [PDF]

Frontiers in Oncology, 2013
The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence.
GALATI, Alessandra, MICHELI, EMANUELA, CACCHIONE, Stefano   +2 more
openaire   +4 more sources

THE STRUCTURE AND FUNCTION OF CHROMATIN AND CHROMOSOMES [PDF]

Biocomputing 2012, 2011
1. Background One of the striking features of the eukaryotic nucleus is that chromosomes adopt preferred conformations that vary across different tissues and developmental stages. Many lines of evidence suggest the functional significance of genome architecture, including the existence of chromosomes territories [1], the correlation between radial ...
William Stafford Noble, C. Anthony Blau, Job Dekker, Zhi-jun Duan, Yi Mao   +4 more
openaire   +2 more sources

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

Nature Communications, 2019
Kinetochore function depends on H4K20 monomethylation in centromeric nucleosomes but the underlying mechanism is unclear. Here, the authors provide evidence that the centromere-specific nucleosome subunit CENP-A facilitates H4K20 methylation by enabling ...
Yasuhiro Arimura, Hiroaki Tachiwana, Hiroki Takagi, Tetsuya Hori, Hiroshi Kimura, Tatsuo Fukagawa, Hitoshi Kurumizaka   +6 more
doaj   +1 more source

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Nature Communications, 2019
Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into ...
Marcus D. Wilson, Ludovic Renault, Daniel P. Maskell, Mohamed Ghoneim, Valerie E. Pye, Andrea Nans, David S. Rueda, Peter Cherepanov, Alessandro Costa   +8 more
doaj   +1 more source

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Nature Communications, 2021
Understanding the pathology and immunological response to SARS CoV2 infection in specific patient groups is essential for informing the scientific and clinical handling of infections within these patient populations.
Aljawharah Alrubayyi, Ester Gea-Mallorquí, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa   +20 more
doaj   +1 more source

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells [PDF]

, 2002
Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages.
Bonifer, Constanze, Pieter J.M. Leenen, Himes, R, Clarke, D, Himes, Roy, Riggs, A. D., Bonifer, Constanze; id_orcid, Tagoh, H., Tagoh, Hiromi, Hume, David, Himes, R., Tagoh, H, Hume, D., Leenen, PJ, Roy Himes, Clarke, D., Bonifer, C, Leenen, Pieter J M, Constanze Bonifer, David Hume, Riggs, AD, Bonifer, C., Leenen, P. J. M., Arthur D. Riggs, Leenen, Pieter, Clarke, Deborah, Hiromi Tagoh, Deborah Clarke, Riggs, Arthur D, Hume, D   +29 more
core   +1 more source

Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome

Nature Communications
In mammalian global genomic nucleotide excision repair, UV-DDB plays a central role in recognizing DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers, within chromatin.
Syota Matsumoto, Yoshimasa Takizawa, Mitsuo Ogasawara, Kana Hashimoto, Lumi Negishi, Wenjie Xu, Haruna Tachibana, Junpei Yamamoto, Shigenori Iwai, Kaoru Sugasawa, Hitoshi Kurumizaka   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural basis of RNAPII transcription on the nucleosome containing histone variant H2A.B

The EMBO Journal
H2A.B is a distant histone H2A variant associated with actively transcribed regions of the genome, suggesting its positive role in promoting transcription.
Munetaka Akatsu, Rina Hirano, Tomoya Kujirai, Mitsuo Ogasawara, Haruhiko Ehara, Shun-ichi Sekine, Yoshimasa Takizawa, Hitoshi Kurumizaka   +7 more
doaj   +1 more source