Results 21 to 30 of about 272,086 (309)
Unbiased high-throughput characterization of mussel transcriptomic responses to sublethal concentrations of the biotoxin okadaic acid [PDF]
PeerJ, 2015 Background. Harmful Algal Blooms (HABs) responsible for Diarrhetic Shellfish Poisoning (DSP) represent a major threat for human consumers of shellfish. The biotoxin Okadaic Acid (OA), a well-known phosphatase inhibitor and tumor promoter, is the primary ...
Victoria Suarez-Ulloa +7 more
doaj +2 more sources
The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]
, 2012 The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P. +44 more
core +1 more source
Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
doaj +1 more source
Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]
, 2009 We present a quantitative Forster resonance energy transfer (FRET)-based assay using multiphoton fluorescence lifetime imaging microscopy (FLIM) to measure chromatin compaction at the scale of nucleosomal arrays in live cells. The assay uses a human cell
Angus I. Lamond +11 more
core +1 more source
The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring
FEBS Open Bio, 2023 The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding.
Chiaki Kinoshita +5 more
doaj +1 more source
Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
core +1 more source
Identification and validation of transcription factors that regulate chromatin dynamics [PDF]
, 2012 Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core +1 more source
Chromatin and nucleosome structure [PDF]
Nucleic Acids Research, 1976 Chromatin nucleosomes (mononucleosomes through pentanucleosomes) have been isolated by staphylococcal nuclease digestion of calf thymus nuclei. The peak value ellipticity is the same for all oligomers, 1900 deg cm2, mol-1 at 280-nm, 23 degrees C. The dh280/dT vs T show a progressive increase in Tm of the main thermal band (73.5 degrees C, monomer; 79 ...
R, Mandel, G D, Fasman
openaire +2 more sources
A model for chromatin structure [PDF]
Nucleic Acids Research, 1975 A model for chromatin structure is presented. (a) Each of four histone species, H2A (IIbl or f2a2), H2B (IIb2 or f2b), H3 (III or f3) and H4 (IV or f2al) can form a parallel dimer. (b) These dimers can form two tetramers, (H2A)2(H2b)2 and (H3)2(H4)2. (C) These two tetramers bind a segment of DNA and condense it into a "C" segments.
openaire +2 more sources
, 2010 Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core +1 more source