Results 21 to 30 of about 7,699,681 (297)
Nature Communications, 2021 Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
Michal S. Barski +10 more
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Job Opening for Nucleosome Mechanic: Flexibility Required
Cells, 2020 The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical ...
Mary Pitman +2 more
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Unbiased high-throughput characterization of mussel transcriptomic responses to sublethal concentrations of the biotoxin okadaic acid [PDF]
PeerJ, 2015 Background. Harmful Algal Blooms (HABs) responsible for Diarrhetic Shellfish Poisoning (DSP) represent a major threat for human consumers of shellfish. The biotoxin Okadaic Acid (OA), a well-known phosphatase inhibitor and tumor promoter, is the primary ...
Victoria Suarez-Ulloa +7 more
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Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
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Chromatin and nucleosome structure [PDF]
Nucleic Acids Research, 1976 Chromatin nucleosomes (mononucleosomes through pentanucleosomes) have been isolated by staphylococcal nuclease digestion of calf thymus nuclei. The peak value ellipticity is the same for all oligomers, 1900 deg cm2, mol-1 at 280-nm, 23 degrees C. The dh280/dT vs T show a progressive increase in Tm of the main thermal band (73.5 degrees C, monomer; 79 ...
R, Mandel, G D, Fasman
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A model for chromatin structure [PDF]
Nucleic Acids Research, 1975 A model for chromatin structure is presented. (a) Each of four histone species, H2A (IIbl or f2a2), H2B (IIb2 or f2b), H3 (III or f3) and H4 (IV or f2al) can form a parallel dimer. (b) These dimers can form two tetramers, (H2A)2(H2b)2 and (H3)2(H4)2. (C) These two tetramers bind a segment of DNA and condense it into a "C" segments.
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The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring
FEBS Open Bio, 2023 The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding.
Chiaki Kinoshita +5 more
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NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]
, 2004 Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
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Chromatin Structure in Telomere Dynamics [PDF]
Frontiers in Oncology, 2013 The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence.
GALATI, Alessandra +2 more
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THE STRUCTURE AND FUNCTION OF CHROMATIN AND CHROMOSOMES [PDF]
Biocomputing 2012, 2011 1. Background One of the striking features of the eukaryotic nucleus is that chromosomes adopt preferred conformations that vary across different tissues and developmental stages. Many lines of evidence suggest the functional significance of genome architecture, including the existence of chromosomes territories [1], the correlation between radial ...
William Stafford Noble +4 more
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