Results 11 to 20 of about 7,699,681 (297)

Telomeric chromatin structure

Current Opinion in Structural Biology, 2022
Eukaryotic DNA is packaged into nucleosomes, which further condenses into chromosomes. The telomeres, which form the protective end-capping of chromosomes, play a pivotal role in ageing and cancer. Recently, significant advances have been made in understanding the nucleosomal and telomeric chromatin structure at the molecular level. In addition, recent
Aghil Soman, Nikolay Korolev, Lars Nordenskiöld   +2 more
openaire   +4 more sources

Chromatin structure in cancer

BMC Molecular and Cell Biology, 2022
In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains, and larger chromatin compartments ...
Meng Wang, Benjamin D. Sunkel, William C. Ray, Benjamin Z. Stanton   +3 more
doaj   +3 more sources

Live-cell visualisation of chromatin for the study of radiation-induced chromosome aberrations [PDF]

, 2011
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Chromosomes can be visualised during the metaphase stage of the cell cycle however, there are various limitations associated with the visualisation of ...
Malis, Georgios
core   +7 more sources

The Structure of Chromatin [PDF]

Proceedings of the National Academy of Sciences, 1971
The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action on DNA complexed with protein in ...
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Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA [PDF]

, 2010
Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core   +1 more source

Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae [PDF]

, 2009
Background In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect.
Esther R Loney, Pryde, Fiona E., Louis Edward J, F. E. Pryde (7675940), Mellor, J., P. W. Inglis (7675937), Nicholas A Kent, J. Mellor (27566), Pryde Fiona E, Mellor Jane, Sharp Sarah, Kent Nicholas A, Loney, E. R., Sharp, Sarah, Sharp, S., Edward John Louis (7604981), S. Sharp (7639394), Inglis, Peter W., Louis, Edward J., Inglis, P. W., N. A. Kent (7675943), Peter W Inglis, Loney, Esther R., Kent, Nicholas A., Jane Mellor, Edward J Louis, Pryde, F. E., Louis, E. J., Loney Esther R, Inglis Peter W, E. R. Loney (7675934), Mellor, Jane, Fiona E Pryde, Sarah Sharp   +33 more
core   +1 more source

Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]

, 2012
Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J, Risso Guillermo J., Lleres, D, Jernej Ule, Ignacio E. Schor (120406), Llères, David, Llères David, Pawellek, A., Ule, J., Kornblihtt Alberto R., Schor, Ignacio, E, Risso, GJ, Ule, Jernej, Lamond, Angus I.; id_orcid, Lamond, A.I., Alberto R. Kornblihtt (120413), Lamond, Angus, I, Kornblihtt, Alberto, R, Pawellek, Andrea, Andrea Pawellek, Alberto R Kornblihtt, David Llères (68840), Guillermo J. Risso (120408), Andrea Pawellek (120410), Risso, Guillermo J., Schor*, I.E., Schor, I.E., Lamond Angus I., Schor, Ignacio E., Ule, J, Ule Jernej, Risso, G.J., David Llères, Kornblihtt, A.R., Ignacio E Schor, Pawellek Andrea, Lleres*, D., Lamond, AI, Guillermo J Risso, Angus I Lamond, Kornblihtt, Alberto R., Llères, D., Schor Ignacio E., Pawellek, A, Schor, IE, Angus I. Lamond (13065), Kornblihtt, AR, Jernej Ule (115588)   +47 more
core   +1 more source

Proteomic interrogation of human chromatin. [PDF]

, 2011
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary, Christodoulos A Floudas, Floudas, Christodoulos A., Barry M Zee, Garcia, Benjamin A., Richard C Baliban, Baliban, Richard C., Sandra B Hake, Torrente, Mariana P., Zee, Barry M., Hake, Sandra B., Christodoulos A. Floudas, Barry M. Zee, Nicolas L. Young, Mariana P. Torrente, Gary LeRoy, Richard C. Baliban, Sandra B. Hake, Benjamin A. Garcia, Nicolas L Young, Benjamin A Garcia, Young, Nicolas L., Mariana P Torrente, Torrente Mariana P., Zee Barry M., Young Nicolas L., Hake Sandra B., LeRoy Gary, Garcia Benjamin A., Floudas Christodoulos A., Baliban Richard C.   +30 more
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Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]

, 2012
The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P., Nathke, Inke S.; id_orcid, Ashwat Visvanathan, Daniel Klotz (158368), Inke S Näthke, Visvanathan, Ashwat, Gaganmeet S. Chadha (158365), Klotz Daniel, Swedlow, Jason R.; id_orcid, Visvanathan, A., Näthke, I.S., Chadha, Gaganmeet S., Gaganmeet S Chadha, Lamond Angus, Angus Lamond (158376), Dikovskaya Dina, Visvanathan Ashwat, Dikovskaya, Dina, Näthke Inke S., Lamond, A., Swedlow Jason R., Dina Dikovskaya (158354), Jason R. Swedlow (158382), Inke S. Näthke (158386), Newton Ian P., Lamond, Angus; id_orcid, Newton, I.P., Khoudoli, Guennadi, Khoudoli, G., Angus Lamond, Guennadi Khoudoli (158358), Dikovskaya, D., Daniel Klotz, Klotz, D., Jason R Swedlow, Khoudoli Guennadi, Chadha, G.S., Guennadi Khoudoli, Klotz, Daniel, Dina Dikovskaya, Ian P. Newton (158362), Chadha Gaganmeet S., Ashwat Visvanathan (158372), Swedlow, J.R., Ian P Newton   +44 more
core   +1 more source