Results 101 to 110 of about 6,309 (194)

The proteostasis network and its decline in ageing

, 2019
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core   +1 more source

In silico analysis of TTR gene (coding and non-coding regions, and interactive network) and its implications in transthyretin-related amyloidosis. [PDF]

, 2014
Introduction: Transthyretin (TTR)-related amyloidosis is a life-threatening disease. Currently, several questions about the pathogenic mechanisms of TTR-related amyloidosis remain unanswered.
Di Girolamo, M, Fuciarelli, M, Manfellotto, D, Polimanti, R   +3 more
core   +1 more source

Monitoring the Efficacy of Tafamidis in ATTR Cardiac Amyloidosis by MRI-ECV: A Systematic Review and Meta-Analysis

Tomography
Background: The usefulness of monitoring treatment effect of tafamidis using magnetic resonance imaging (MRI) extracellular volume fraction (ECV) has been reported.
Shingo Kato, Mai Azuma, Nobuyuki Horita, Daisuke Utsunomiya   +3 more
doaj   +1 more source

BRICHOS interactions with amyloid proteins and implications for Alzheimer disease [PDF]

, 2016
To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect failure of the cell to manage ...
Dolfe, Lisa
core   +1 more source

Tafamidis improves myocardial longitudinal strain in A97S transthyretin cardiac amyloidosis

Therapeutic Advances in Chronic Disease
Background: Transthyretin cardiomyopathy (ATTR-CM) is a debilitating disease that has received much attention since the emergence of novel treatments.
Yuan-Kun (Aden) Wu, An-Li Yu, Mei-Fang Cheng, Lung-Chun Lin, Ming-Jen Lee, Chia-Hung Chou, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ping-Huei Tseng, Siao-Ping Lin, Mao-Yuan Su, Chi-Chao Chao, Sung-Tsang Hsieh, Cheng-Hsuan Tsai, Yen-Hung Lin   +15 more
doaj   +1 more source

Tafamidis Meglumine [PDF]

Reactions Weekly, 2020
openaire   +2 more sources

Safety, Tolerability, and Outcomes of Tafamidis for the Treatment of Acquired Amyloid Neuropathy in Domino Liver Transplant Recipients

Neurology and Therapy
Introduction Acquired amyloid neuropathy is an iatrogenic disease that appears years after a domino liver transplant. The objectives of our study are to analyze the efficacy and tolerability of tafamidis for the treatment of acquired amyloid neuropathy ...
Velina Nedkova-Hristova, Laura Donadeu, Carmen Baliellas, José González-Costello, Laura Lladó, Emma González-Vilatarsana, Valentina Vélez-Santamaría, Miosés Morales de la Prida, Oriol Bestard, Carlos Casasnovas   +9 more
doaj   +1 more source

Regression of LV hypertrophy by tafamidis [PDF]

, 2022
Transthyretin amyloidosis (ATTR) variant is a life-threatening hereditary disease predominantly affecting the peripheral nervous system and heart. Tafamidis, which prevents the deposition of amyloid by stabilizing transthyretin, is available for the ...
Fukuda, Daiju, Hara, Tomoya, Ise, Takayuki, Kadota, Muneyuki, Kawabata, Yutaka, Kusunose, Kenya, Matsuura, Tomomi, Osaki, Yusuke, Saijo, Yoshihito, Sata, Masataka, Soeki, Takeshi, Tserensonom, Munkhtsetseg, Ueno, Rie, Wakatsuki, Tetsuzo, Yagi, Shusuke, Yamada, Hirotsugu, Yamaguchi, Koji, Yamazaki, Hiromu   +17 more
core  

Efficacy and Safety of Tafamidis Doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT)

Journal of Cardiac Failure, 2019
Introduction Tafamidis was shown to be an effective treatment for transthyretin amyloid cardiomyopathy (ATTR-CM) in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT). Hypothesis While ATTR-ACT was not designed for a definitive assessment by dose, further analysis may assist determination of the optimal dose.
Mazen Hanna, Thibaud Damy, Pablo Garcia-Pavia, Daniel P. Judge, Giampaolo Merlini, Mathew S. Maurer, Balarama Gundapaneni, Terrell A. Patterson, Jeffrey H. Schwartz, Marla B. Sultan, Ronald Witteles   +10 more
openaire   +1 more source

Management of Cardiac Amyloidosis: A Narrative Review

Journal of the Practice of Cardiovascular Sciences
Amyloidosis is a multi-system disorder in which cardiac involvement often manifests with heart failure and/or arrhythmias. Recognition of cardiac amyloidosis is important as it is a potentially treatable cause of cardiomyopathy.
Neha Chopra, Rishi Dhawan, Sandeep Seth
doaj   +1 more source