Results 91 to 100 of about 1,018 (169)

Idiopathic Multicentric Castleman Disease With Severe Eosinophilia and Diffuse Centrilobular Nodule—A Rare Case Report

Case Reports in Hematology, Volume 2025, Issue 1, 2025.
Rationale Idiopathic multicentric Castleman disease (iMCD), also known as angiofollicular lymph node hyperplasia, is a rare inflammatory lymphoproliferative disease with diverse clinical presentations. We report a rare case of iMCD accompanied by severe eosinophilia and diffuse centrilobular pulmonary nodules, which have rarely been previously ...
Xiaojuan Li, Shuang Li, Tianming Zhao, Biao Xu, Xinge Du, Xinyu Song, Yingnan Wang, Suraiya Saleem   +7 more
wiley   +1 more source

Interleukin‐6 transcripts up‐regulation in lymph nodes from unicentric and multicentric Castleman disease

eJHaem, Volume 5, Issue 6, Page 1182-1189, December 2024.
Abstract Introduction Castleman disease (CD) represents a spectrum of heterogeneous lymphoproliferative disorders sharing peculiar histopathological features, clinically subdivided into unicentric CD (UCD) and multicentric CD (MCD) and presenting with variable inflammatory symptoms.
Marco Lucioni, Gaia Morello, Caterina Cristinelli, Sara Fraticelli, Giuseppe Neri, Erica Travaglino, Marco Minetto, Francesca Antoci, Paolo Libretti, Marcello Gambacorta, Luca Arcaini, Claudio Tripodo, Marco Paulli   +12 more
wiley   +1 more source

Tafro Syndrome - Mimicker of SLE

Journal of Clinical Rheumatology and Immunology
Background: TAFRO SYNDROME mimics SLE. Differentiating both is essential for correct manangement. Case report: 40 year old lady came with complaints of fever, insidious onset of painless abdominal distension which was gradually progressive to form tense ascities in a span of 2 months.
Manikandan Gopal, John Mathew
openaire   +2 more sources

Sjögren's syndrome manifesting as clinicopathological features of TAFRO syndrome

Medicine, 2017
TAFRO syndrome is a newly proposed disorder that manifests as thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. In this report, we describe the development of severe TAFRO syndrome-like systemic symptoms during the clinical course of juvenile-onset Sjögren's syndrome in a 32-year-old woman.The patient was ...
Fujimoto, Shino, Kawabata, Hiroshi, Kurose, Nozomu, Kawanami-Iwao, Haruka, Sakai, Tomoyuki, Kawanami, Takafumi, Fujita, Yoshimasa, Fukushima, Toshihiro, Masaki, Yasufumi   +8 more
openaire   +2 more sources

Idiopathic multicentric Castleman disease with marrow fibrosis and extramedullary hematopoiesis

European Journal of Haematology, Volume 113, Issue 6, Page 833-841, December 2024.
Abstract Background Idiopathic multicentric Castleman disease (iMCD) is a rare inflammatory disorder mediated by excessive proinflammatory cytokine signaling, most notably by interleukin 6 (IL‐6). IL‐6‐induced extramedullary hematopoiesis (EMH) has been reported in murine models of iMCD. Herein we present four cases of iMCD with EMH in humans.
Marley Blommers, Sorin Selegean, Richard K. Wood, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, E. Ashley Wiley, Emilie Comeau, Allam A. Shawwa, Stefan Rose‐John, David C. Fajgenbaum, Luke Y. C. Chen   +10 more
wiley   +1 more source

Pediatric TAFRO syndrome: A multi‐institution case series illustrating clinical challenges and excellent outcomes

Pediatric Blood &Cancer, Volume 71, Issue 10, October 2024.
Abstract A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose ...
Amanda K. Johnson, Sasidhar Goteti, Bar Devald, Shelby Mestnik, Taumoha Ghosh, Robin Williams, Elizabeth S. Doughty, Michael A. Linden, Amy Beckman, Todd Williams, Kelsey Richardson, Marie Martinelli   +11 more
wiley   +1 more source

A hypothesis on treatment strategy of severe multicentric Castleman disease with continuous renal replacement therapy

Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.
Abstract Castleman disease (CD) is a rare lymphoproliferative disorder, with non‐specific clinical manifestations, often delayed diagnosis and treatment, which pose a significant challenge in the present times. Patients diagnosed with this disease have poor prognosis due to the limited treatment options.
Cătălin Constantinescu, David Kegyes, Bogdan Tigu, Vlad Moisoiu, Olga Grăjdieru, Andrea Szekely, Evangelos Terpos, Ciprian Tomuleasa   +7 more
wiley   +1 more source

Value of hemophagocytosis in the diagnosis of hemophagocytic lymphohistiocytosis in critically ill patients

European Journal of Haematology, Volume 112, Issue 6, Page 917-926, June 2024.
Abstract Background Ferritin is an established biomarker in the diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH), which is diagnosed by the HLH‐2004 criteria. Among these criteria, detection of hemophagocytosis through invasive procedures may delay early life saving treatment.
Peter Nyvlt, Friederike S. Schuster, Jana Ihlow, Patrick Heeren, Claudia Spies, Josephine Hiesgen, Thomas Schenk, Ann‐Christin von Brünneck, Jörg Westermann, Frank M. Brunkhorst, Paul La Rosée, Gritta Janka, Cornelia Lachmann, Gunnar Lachmann   +13 more
wiley   +1 more source

The application of a multidisciplinary approach in the diagnosis of Castleman disease and Castleman‐like lymphadenopathies: A 20‐year retrospective analysis of clinical and pathological features

British Journal of Haematology, Volume 204, Issue 2, Page 534-547, February 2024.
Summary Background Castleman disease (CD) comprises a group of rare and heterogeneous haematological disorders, including unicentric (UCD) and multicentric (MCD) forms, the latter further subdivided into HHV8‐MCD, POEMS‐MCD and idiopathic‐MCD (iMCD). However, according to the Castleman Disease Collaborative Network guidelines, the diagnosis of CD can ...
Sabrina Pelliccia, Evelina Rogges, Antonello Cardoni, Gianluca Lopez, Esmeralda Conte, Anna Laura Faccini, Rita De Vito, Katia Girardi, Antonella Bianchi, Ombretta Annibali, Stefano Fratoni, Daniele Remotti, Gioia De Angelis, Carla Giordano, Giovanna Palumbo, Stefania Scarpino, Flavia Del Porto, Maria Paola Bianchi, Francesca Di Gregorio, Agostino Tafuri, Arianna Di Napoli   +20 more
wiley   +1 more source

A case of idiopathic multicentric Castleman's disease with secondary autoimmune neutropenia

Respirology Case Reports, Volume 12, Issue 1, January 2024.
Thrombocytopenia and anaemia are common complications of Idiopathic multicentric Castleman's disease (iMCD)‐induced hematologic disorders, however, neutropenia associated with iMCD is rare. The association between iMCD and autoimmune neutropenia (AIN) involving anti‐neutrophil antibodies has not yet been elucidated.
Toshiki Morimoto, Takako Kawaguchi, Kei Yamasaki, Tatsuya Shingu, Hiroaki Ikegami, Hiroki Dosaka, Yuichi Murata, Yoshinori Kawabata, Kazuhiro Yatera   +8 more
wiley   +1 more source