Results 81 to 90 of about 1,018 (169)

Clinical Presentation, Treatment, and Outcomes of 28 Patients With Castleman Disease: A Retrospective Analysis of an Italian Cohort

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Background Castleman disease (CD) encompasses a range of heterogeneous non‐clonal lymphoproliferative disorders, including unicentric (UCD), and multicentric (MCD) forms. The latter is subdivided into HHV‐8+ MCD, POEMS‐MCD, and idiopathic‐MCD, not otherwise specified (iMCD‐NOS).
Caterina Cristinelli, Michele Merli, Marco Lucioni, Manuel Gotti, Roberta Sciarra, Sara Rattotti, Federico Carpi, Gianmarco Favrin, Benedetta Bianchi, Giuseppe Neri, Marta Coscia, Marcello Gambacorta, Francesco Passamonti, Marco Paulli, Luca Arcaini   +14 more
wiley   +1 more source

The Evolution and Recent Advances in Diagnostic Criteria for Idiopathic Multicentric Castleman Disease

American Journal of Hematology, Volume 100, Issue 11, Page 2064-2073, November 2025.
Idiopathic Multicentric Castleman Disease. ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare cytokine‐driven disorder characterized by systemic inflammation, organ dysfunction, and altered lymph node microscopic architecture. Over the past decade, diagnostic criteria have evolved significantly, integrating clinical, histopathological,
FNU Alnoor, Nicholas C. Spies, Jyoti Kumar, Peyman Samghabadi, Oscar Silva, Matt X. Luo, Karen M. Chisholm, Jingjing Zhang, Alexandra Rangel, David Ng, Peng Li, Robert S. Ohgami   +11 more
wiley   +1 more source

Computed tomography findings of idiopathic multicentric Castleman disease subtypes [PDF]

This study retrospectively evaluated the computed tomography (CT) findings of idiopathic multicentric Castleman disease (iMCD) at a single center and compared the CT findings of iMCD-TAFRO with those of iMCD-non-TAFRO.
Asahara, Takashi, Hiraki, Takao, Iguchi, Toshihiro, Iwaki, Noriko, Kojima, Katsuhide, Maeda, Yoshinobu, Nishikori, Asami, Nishimura, Midori Filiz, Otsuka, Fumio, Sato, Yasuharu   +9 more
core   +1 more source

International Consensus Histopathological Criteria for Subtyping Idiopathic Multicentric Castleman Disease Based on Machine Learning Analysis

American Journal of Hematology, Volume 100, Issue 9, Page 1502-1512, September 2025.
ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder classified into three recognized clinical subtypes—idiopathic plasmacytic lymphadenopathy (IPL), TAFRO, and NOS. Although clinical criteria are available for subtyping, diagnostically challenging cases with overlapping histopathological features highlight ...
Midori Filiz Nishimura, Tomoka Haratake, Yoshito Nishimura, Asami Nishikori, Remi Sumiyoshi, Hideki Ujiie, Yuri Kawahara, Tomohiro Koga, Masao Ueki, Dorottya Laczko, Eric Oksenhendler, David C. Fajgenbaum, Frits van Rhee, Atsushi Kawakami, Yasuharu Sato   +14 more
wiley   +1 more source

To and TAFRO – a cryptic cause of acute renal failure: a case report

BMC Nephrology, 2022
Background TAFRO syndrome is a rare clinical subtype of idiopathic multicentric Castlemans disease characterised by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. Renal involvement is common, sometimes requiring temporary
N. Shah, T. Davidson, C. Cheung, K. Keung   +3 more
doaj   +1 more source

The first report of adolescent TAFRO syndrome, a unique clinicopathologic variant of multicentric Castleman’s disease [PDF]

, 2014
BACKGROUND: TAFRO syndrome is a unique clinicopathologic variant of multicentric Castleman’s disease that has recently been identified in Japan. It is characterized by a constellation of symptoms: Thrombocytopenia, Anasarca, reticulin Fibrosis of the ...
Akihiro Yachie, Akira Hayakawa, Eiryu Kyo, Goichi Kageyama, Hiroshi Nagai, Ikuko Kubokawa, Kazumoto Iijima, Keiichiro Uehara, Masaru Kojima, Nobuyuki Yamamoto, Satoshi Hirase, Takeshi Mori, Tomoko Yanai, Yasuhiro Takeshima   +13 more
core   +1 more source

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

Heterogeneous Presentations of iMCD: A Single‐Institution Case Series

Case Reports in Hematology, Volume 2025, Issue 1, 2025.
Background Idiopathic multicentric Castleman disease (iMCD) is a rare lymphadenopathic disorder characterized by hyperplasia of multiple lymph nodes and can be associated with a wide range of symptoms and presentations, from mild disease to life‐threatening organ failure.
Jaspreet Kaur, Anthony Sisk, Jonathan E. Zuckerman, Haifaa Abdulhaq, Kalyani Sen   +4 more
wiley   +1 more source

Histopathologic findings of TAFRO syndrome with immunohistochemical analysis of the kidney specimen: A case report

Human Pathology: Case Reports, 2021
TAFRO (Thrombocytopenia, Anasarca, Fever and/or elevated C-reactive protein, Renal dysfunction or Reticulin fibrosis, and Organomegaly) syndrome is a unique systemic inflammatory disease, which has recently been proposed from Japan.
Taiki Sato, Yuko Ono, Jun Matsushima, Akiko Fujii, Yoko Sato, Yuji Hidaka, Shinya Kawamoto, Atsunori Yoshino, Tetsuro Takeda, Yoshihiko Ueda, Shinichi Ban   +10 more
doaj   +1 more source

Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease [PDF]

Idiopathic multicentric Castleman disease (iMCD) is a type of Castleman disease unrelated to the Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV8) infection.
Chijimatsu, Ryota, Ennishi, Daisuke, Haratake, Tomoka, Kawahara, Yuri, Lai, You Cheng, Momose, Shuji, Nakamura, Naoya, Nishikori, Asami, Nishimura, Midori Filiz, Ochi, Sayaka, Sato, Yasuharu, Takeda, Yudai, Tomida, Shuta, Ueta, Himawari   +13 more
core   +1 more source