Results 61 to 70 of about 766 (168)

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

The Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen, Xiaoning Wang, Sarandeep Boyanapalli, Lee Anderson, Thao Dang, Guan Xing, Marianna Calvet, Tiffany Hart, Sreeneeranj Kasichayanula, Xiaochen Zhao   +9 more
wiley   +1 more source

Blastic Plasmacytoid Dendritic Cell Neoplasm BPDCN

Hematology, Transfusion and Cell Therapy, 2023
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with an aggressive clinical course and poor prognosis. BPDCN is most often characterized by its presentation with cutaneous lesions which are often asymptomatic, can be
Hanan Hamed
doaj   +1 more source

CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies [PDF]

, 2020
CD123, the α chain of the interleukin 3 receptor, is a cytokine receptor that is overexpressed in multiple hematolymphoid neoplasms, including acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, acute lymphoblastic leukemia, hairy
Edouard Dupont, Paul, Shilpa, Hanadi El Achi, Khoury, Joseph D, Shilpa Paul, El Achi, Hanadi, Joseph D. Khoury, Dupont, Edouard   +7 more
core   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

NEOPLASIA DE CÉLULAS DENDRÍTICAS PLASMOCITÁRIAS BLÁSTICAS: RELATO DE CASO

Hematology, Transfusion and Cell Therapy, 2023
Introdução: A neoplasia de células dendríticas plasmocitárias blásticas (NCDPB) é uma neoplasia hematológica rara e agressiva, que se manifesta como lesões cutâneas com ou sem envolvimento da medula óssea e disseminação leucêmica.
NM Bernardes, WSV Júnior, LMB Batista, SEBJ Neves, SS Custodio, TG Teixeira, TV Lourenço, RG Silva, ABF Glória, FL Nogueira   +9 more
doaj   +1 more source

Multiple Genomic Alterations, Including a Novel AFF4::IRF1 Fusion Gene, in a Treatment-Refractory Blastic Plasmacytoid Dendritic-Cell Neoplasm: A Case Report and Literature Review

, 2023
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with an aggressive clinical course and poor prognosis. The genetic abnormalities in BPDCN are heterogeneous; therefore, its molecular pathogenesis and the prognostic ...
Jianming Pei, Reza Nejati, Joseph R. Testa, Nashwa Mansoor, Michael Styler, Y. Lynn Wang, Yavuz Sahin   +6 more
core   +1 more source

Chemotherapy Options for Blastic Plasmacytoid Dendritic Cell Neoplasm

, 2020
BPDCN is ultimately a bone marrow disease requiring induction-type eradication therapy followed by hematopoietic stem cell transplant (HSCT) to achieve long-lasting remissions or cure.
Haddadin, Michael, Taylor, Justin
core   +1 more source

Blastic Plasmacytoid Dendritic Cell Neoplasm in an Adolescent Managed in a Resource‐Limited Setting: A Case Report

Case Reports in Hematology, Volume 2026, Issue 1, 2026.
Blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are rare, aggressive haematologic malignancies, uncommon in adolescents and often difficult to diagnose. We report a 16‐year‐old male presenting with lymphadenopathy, pancytopenia and constitutional symptoms.
Garrick Laudin, Jenifer Vaughan, Sugeshnee Pather, Claudia Summers, Avishkar Maney, Atul Lakha, Muhammed Faadil Waja, Lindokuhle Goqwana, Katherine Hodkinson, Kalyani Sen   +9 more
wiley   +1 more source

NEOPLASIA DENDRÍTICA PLASMOCITÓIDE BLÁSTICA EM PACIENTE PEDIÁTRICO

Hematology, Transfusion and Cell Therapy, 2023
Objetivo: Relatar uma doença rara em faixa etária atípica. Materiais e métodos: Os dados deste trabalho foram obtidos de revisão de prontuário e revisão da literatura.
BL Souza, AM Carvalho, JF Lopes, MG Duarte, MJS Vasconcelos, MM Dias, WWF Costa, ACB Bomfim, WGG Fischer, PR Fonseca   +9 more
doaj   +1 more source

CD123 a Therapeutic Target for Acute Myeloid Leukemia and Blastic Plasmocytoid Dendritic Neoplasm

, 2023
In spite of consistent progress at the level of basic research and of clinical treatment, acute myeloid leukemia (AML) still represents an unmet clinical need for adult and pediatric patients. To improve the outcomes of these patients, it is necessary to
Elvira Pelosi, Germana Castelli, Ugo Testa, Pelosi, Elvira, Castelli, Germana, Testa, Ugo   +5 more
core   +1 more source