Results 51 to 60 of about 22,232 (271)

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Sensitivity of tail rotor noise to helicopter configuration in forward flight [PDF]

, 2009
Understanding the mechanisms that lead to the production of noise by tail rotors across a broad range of flight conditions and helicopter configurations remains an active area of research.
Fletcher, Timothy M., Brown, R.E., Fletcher, T.M., Duraisamy, K., Duraisamy, Karthikeyan, Brown, Richard   +5 more
core  

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Failure of a Tail Rotor Blade in a Helicopter [PDF]

, 2005
Abstract A helicopter lost the outboard rib on a tail rotor blade in flight and was forced to land because of the resulting vibrations. The investigation that followed is described in this chapter along with key findings. As shown in a sketch, the rib is held in place by a set of six rivets.
openaire   +2 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

RESULTS OF THE FIRST MI-171A2 FLYING LABORATORY TEST PHASE

Научный вестник МГТУ ГА, 2014
The present publication describes the results of the first stage of the flying laboratory (Mi-171 helicopter) flight tests performed at Mil Moscow Helicopter Plant, JSC facilities. Main rotor components with blades made of polymer composite materials and
V. A. Ivchin, K. Y. Samsonov
doaj   +1 more source

Interactional aerodynamics and acoustics of a propeller-augmented compound coaxial helicopter [PDF]

, 2008
The aerodynamic and acoustic characteristics of a generic hingeless coaxial helicopter with a tail-mounted propulsor and stabiliser have been simulated using Brown's Vorticity Transport Model.
Kim, Hyo Wan, Kenyon, Adam R., Duraisamy, Karthikeyan, Brown, Richard   +3 more
core  

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Design of Unmanned Helicopter Distributed Electric Tail Rotor Controller Based on Improved Active Disturbance Rejection Control

IEEE Access
In response to the critical implications of single tail rotor failures in unmanned helicopters, this study proposes a distributed electric tail rotor yaw channel controller that employs Active Disturbance Rejection Control (ADRC) techniques.
Qing-Xin Zhang, Yun-Feng Ji, Feng Wang, Lei Pei, Zheng-Ming Cha   +4 more
doaj   +1 more source

Mathematical Modeling and Stability Analysis of Tiltrotor Aircraft

Drones, 2022
The key problem in the development process of a tiltrotor is its mathematical modeling. Regarding that, this paper proposes a dividing modeling method which divides a tiltrotor into five parts (rotor, wing, fuselage, horizontal tail, and vertical fin ...
Hanlin Sheng, Chen Zhang, Yulong Xiang
doaj   +1 more source