Results 71 to 80 of about 47,594 (303)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Journal of Degraded and Mining Lands ManagementArtisanal and small-scale gold mining (ASGM) activities still use mercury (Hg) for the amalgamation processing step. These ASGM activities generate tailings as a mining by-product, representing the primary source of environmental Hg contamination.
Wawan Budianta +4 more
doaj +1 more source
Variation of Pore Water Pressure in Tailing Sand under Dynamic Loading
Shock and Vibration, 2018 Intense vibration affects the pore water pressure in a tailing dam, with the tendency to induce dam liquefaction. In this study, experiments were performed wherein model tailing dams were completely liquefied by sustained horizontal dynamic loading to ...
Jia-xu Jin +4 more
doaj +1 more source
MEASURING THE ANTECEDENT EFFECTS OF SERVICE COGNITION AND INTERNET SHOPPING ANXIETY ON CONSUMER SATISFACTION WITH E-TAILING SERVICE [PDF]
Internet shopping anxiety (ISA), or the negative emotion that results from an individual’s experiences with online shopping in particular, is an important factor to explain the consumer’s emotion in ecommerce usage experience, such as e-tailing service ...
Chengwen YAO, Shuling LIAO
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Degraded and Mining Lands ManagementArtisanal and small-scale gold mining has commonly used the mercury amalgamation method for gold ore extraction. The processing waste or tailings often contain gold and other metals.
Rhazista Noviardi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source