Results 71 to 80 of about 113,227 (308)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Identifying the origins of local atmospheric deposition in the steel industry basin of Luxembourg using the chemical and isotopic composition of the lichen Xanthoria parietina [PDF]

, 2008
Trace metal atmospheric contamination was assessed in one of the oldest European industrial sites of steel production situated in the southern part of the Grand-Duchy of Luxembourg.
Geagea, Majdi Lahd, Hissler, Christophe, Hoffmann, Lucien, Krein, Andreas, Perrone, Thierry, Probst, Jean-Luc, Stille, Peter   +6 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The use of sequential extraction procedure for mercury fractionation study in gold mining tailings: implications for environmental pollution

Journal of Degraded and Mining Lands Management
Artisanal and small-scale gold mining (ASGM) activities still use mercury (Hg) for the amalgamation processing step. These ASGM activities generate tailings as a mining by-product, representing the primary source of environmental Hg contamination.
Wawan Budianta, Arifudin Idrus, Fahmi Hakim, Augustus C. Resurrection, Hirofumi Hinode   +4 more
doaj   +1 more source

Variation of Pore Water Pressure in Tailing Sand under Dynamic Loading

Shock and Vibration, 2018
Intense vibration affects the pore water pressure in a tailing dam, with the tendency to induce dam liquefaction. In this study, experiments were performed wherein model tailing dams were completely liquefied by sustained horizontal dynamic loading to ...
Jia-xu Jin, Hong-zhi Cui, Li Liang, Shi-wang Li, Ping-yi Zhang   +4 more
doaj   +1 more source

Modeling the formation of high metal concentration zones in man-made deposits [PDF]

, 2018
Purpose. To study conditions of forming the zones of high metal concentration in metal-containing man-made deposits. To assess the likelihood of metal concentration in the placer core. Methods.
Korniienko, V, Malanchuk, Ye, Malanchuk, Z, Soroka, V, Vasylchuk, O   +4 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The effect of cow manure amendment and the ratio of gold mine tailings on sweet potato gold phytomining

Journal of Degraded and Mining Lands Management
Artisanal and small-scale gold mining has commonly used the mercury amalgamation method for gold ore extraction. The processing waste or tailings often contain gold and other metals.
Rhazista Noviardi, Benny Joy, Rija Sudirja, Mieke Rochimi Setiawati, Muhamad Rachman Djuwansah, Agung Karuniawan, Emma Trinurani Sofyan, Pujawati Suryatmana   +7 more
doaj   +1 more source

Kajian Sifat Mekanik Beton Tailing Pada Pengecoran Dalam Air Dengan Menggunakan Bahan Tambah Sikacrete-w [PDF]

, 2013
Tailing merupakan sisa pengolahan tambang (limbah) yang tidak dikelola sehingga hanya ditampung atau dialirkan ke sungai dekat lokasi penambangan. Dampak lingkungan akibat limbah tailing ini dapat dikurangi dengan memanfaatkannya sebagai substitusi semen.
Kuhu, H. Y. (Hanna), Pandaleke, R. (Ronny), Sumajouw, M. D. (Marthin), Tamboto, W. J. (Winny)   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source